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Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis.
Paracrine signalling between the oocyte and its surrounding somatic cells is fundamental to the processes of oogenesis and folliculogenesis in mammals. The study of animal models has revealed thatExpand
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DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.
Trp63, a transcription factor related to the tumor suppressor p53, is activated by diverse stimuli and can initiate a range of cellular responses. TAp63 is the predominant Trp53 family member inExpand
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Apoptosis in the germ line.
Apoptosis is a critical process for regulating both the size and the quality of the male and female germ lines. In this review, we examine the importance of this process during embryonic developmentExpand
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KIT/KIT Ligand in Mammalian Oogenesis and Folliculogenesis: Roles in Rabbit and Murine Ovarian Follicle Activation and Oocyte Growth1
Abstract In rodent ovaries Kit ligand (KITL) and its receptor KIT have diverse roles, including the promotion of primordial follicle activation, oocyte growth, and follicle survival. Studies wereExpand
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Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary
The HLH transcriptional regulator Id4 exerts important roles in different organs, including the neural compartment, where Id4 loss usually results in early lethality. To explore the role of thisExpand
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Primordial follicle activation and follicular development in the juvenile rabbit ovary
Of all the stages of mammalian folliculogenesis, the primordial to primary follicle transition is the least understood. In order to gain new insights into this process, we have conducted aExpand
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What is the "ovarian reserve"?
Ovarian reserve (OR) can be defined as the quantity and quality of the follicles left in the ovary at any given time. A follicle is a fluid filled sac within which an egg (oocyte) develops. ORExpand
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Comparative analysis of the metaphase II spindle of human oocytes through polarized light and high-performance confocal microscopy.
OBJECTIVE To determine whether Polscope analysis can predict different spindle and chromosome configurations of the oocyte metaphase II (MII) spindle. DESIGN Comparison of Polscope and confocalExpand
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The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion.
Reports indicate that germ-line stem cells present in adult mice can rapidly generate new oocytes and contribute to the primordial follicle reserve following conditions of ovotoxic stress. We furtherExpand
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Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility
Female gametes are stored in the ovary in structures called primordial follicles, the supply of which is non-renewable. It is well established that DNA-damaging cancer treatments can deplete theExpand
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