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Proteome and Peptidome of Vipera berus berus Venom
An attempt was made to identify proteins and peptides derived from this species venom by using high resolution two-dimensional electrophoresis and MALDI ToF/ToF mass spectrometry, and all successfully identified peptides belong to the bradykinin-potentiating peptides family.
Comparison of Methods for Measuring Protein Concentration in Venom Samples
- A. Bocian, Sonja Sławek, +6 authors J. Legáth
- Chemistry, MedicineAnimals : an open access journal from MDPI
- 1 March 2020
Five methods used to measure protein content in venoms of two snake species: the Viperids representative, Agkistrodon contortrix, and the Elapid representative, Naja ashei are compared to help draw attention to the problem of measuring protein concentration, especially in such a complex mixture as animal venoms.
First Look at the Venom of Naja ashei
The main components of analysed venom are 3FTxs (Three-Finger Toxins) and PLA2s (Phospholipases A2) and the presence of cysteine-rich venom proteins, 5′-nucleotidase and metalloproteinases has been confirmed.
Evaluation of Antifungal Activity of Naja pallida and Naja mossambica Venoms against Three Candida Species
Antifungal activity of snake venoms should be studied with great caution and a plethora of pathogenic biomarkers should be considered in the future experiments.
Proteomic Analyses of Agkistrodon contortrix contortrix Venom Using 2D Electrophoresis and MS Techniques
Ten groups of proteins present in the venom are identified, of which phospholipase A2 and metalloprotease and serine proteases constitute the largest groups, and for the first time presence of 5′-nucleotidase in venom was found in this group of snakes.
An Effective Method of Isolating Honey Proteins
- A. Bocian, Justyna Buczkowicz, M. Jaromin, K. Hus, J. Legáth
- Medicine, ChemistryMolecules
- 29 June 2019
This work proposes a new method of protein isolation from honey based on saturated phenol that is potentially less expensive and less time-consuming than other previously described methods, while being equally effective.
Snake venoms promote stress‐induced senescence in human fibroblasts
- A. Lewinska, A. Bocian, +7 authors M. Wnuk
- Biology, MedicineJournal of cellular physiology
- 14 October 2018
It is shown for the first time that selected snake venoms may also exert adverse effects when used at relatively noncytotoxic concentrations.
Antibacterial properties of snake venom components
Thorough investigations have shown that the phospholipases A 2 and l -amino acids oxidases (LAAO) are mainly responsible for the bactericidal properties of snake venoms, and some preliminary research studies suggest that fragments of three-finger toxins (3FTx) are bactericidal.
Antimicrobial Activity of Protein Fraction from Naja ashei Venom against Staphylococcus epidermidis
A new group of low abundant proteins containing the Ig-like domain that have not been previously described in snake venoms are identified, showing exceptional antimicrobial effects both alone and in combination with antibiotics.
Impact of Zinc Sulfate Exposition on Viability, Proliferation and Cell Cycle Distribution of Epithelial Kidney Cells
- D. Marcinčáková, P. Schusterová, +6 authors J. Legáth
- ChemistryPolish Journal of Environmental Studies
- 28 May 2019
Zinc is an essential trace element effective at very low concentrations, but it is also an important environmental pollutant dangerous after excessive intake or exposure. The aim of this study was to…