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Technical Report: results of immunological tests on faecal extracts are likely to be extremely misleading
- A. Ferguson, K. Humphreys, N. Croft
- Medicine, BiologyClinical and experimental immunology
- 1 January 1995
The data indicate that immunological tests on saline extracts of faeces do not represent the true status of the gut humoral immune system, and such studies should be strongly discouraged.
Whole gut lavage fluid analysis : a minimally invasive method for study of mucosal immunity and inflammation.
- S. Ghosh, A. Dahele, H. Drummond, S. Hoque, K. Humphreys, I. Arnott
- Medicine, BiologyMethods in molecular medicine
The experience of the use of WGLF to study mucosal immunity and inflammation is described, which finds that WGLFs from patients suffering from a variety of intestinal diseases contain immunoglobulins and antibodies, hemoglobin, plasma- derived proteins, cytokines, inflammatory cells, and their granule-derived proteins and growth factors.
Serum IgA tissue transglutaminase antibodies in coeliac disease and other gastrointestinal diseases.
- A. Dahele, M. Aldhous, K. Humphreys, S. Ghosh
- Medicine, BiologyQJM : monthly journal of the Association of…
- 1 April 2001
IgA anti-tTG concentrations were significantly higher in untreated coeliacs than in other groups (Mann-Whitney, p<0.00001) and compared well with IgA EMA titres (r(2)=0.54; p< 0.0001).
Heterogeneity of Celiac Disease: Clinical, Pathological, Immunological, and Genetic
- A. Ferguson, H. Gillett, K. Humphreys, K. Kingstone
- MedicineAnnals of the New York Academy of Sciences
- 1 November 1998
This paper considers recent new data on the pathological features of gluten sensitivity and on the disease‐associated antigens, in the context of a multistage hypothesis that has been developing for the last five years, and it is evident that there are at least five different levels at which genetic influences may operate.
Detection of insulin‐like growth factor‐I and transforming growth factor‐&bgr; in whole gut lavage fluid: a novel method of studying intestinal fibrosis
- Subrata Ghosh, K. Humphreys, M. Papachrysostomou, A. Ferguson
- MedicineEuropean journal of gastroenterology & hepatology
- 1 May 1997
Clinical studies of growth factors in intestinal fluid should facilitate research on intestinal fibrogenesis, and the diagnosis of fibrous stricturing in Crohn's disease.
Intestinal immunology in man
- K. Humphreys
- Biology, Medicine
WGLF was validated as a source of intact intestinal antibodies and anti heavy chain staining of the 55 Kd heavy chahi band was more intense with T-Gel binding as opposed to unfractionated immunoglobulins, indicating that WGLF immunoglobeulins are largely intact and that estimation by ELISA was likely to be quantitative.