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Tandem SH2 binding sites mediate the RasGAP–RhoGAP interaction: a conformational mechanism for SH3 domain regulation
Many cellular signaling proteins contain SH3 (Src homology 3) domains that mediate protein interactions via specific proline‐containing peptides. Unlike SH2 domains, whose interactions withExpand
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Circadian rhythms govern cardiac repolarization and arrhythmogenesis
Sudden cardiac death exhibits diurnal variation in both acquired and hereditary forms of heart disease, but the molecular basis of this variation is unknown. A common mechanism that underliesExpand
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Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker
Human motor control systems orchestrate complex scale-invariant patterns of activity over a wide range of time scales (minutes to hours). The neural mechanisms underlying scale-invariance are unknownExpand
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Circadian misalignment increases cardiovascular disease risk factors in humans
Significance Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease, even after controlling for traditional risk factors. Shift workers frequently undergo circadianExpand
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Antineoplastic agents. III: Steroidal glycosides from Solanum nigrum.
By bioactivity-guided fractionation, three known steroidal glycosides, beta 2-solamargine (1), solamargine (2), and degalactotigonin (3), were isolated from Solanum nigrum. Compounds 1-3 inducedExpand
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Foot pressure distribution during walking in young and old adults
BackgroundMeasurement of foot pressure distribution (FPD) is clinically useful for evaluation of foot and gait pathologies. The effects of healthy aging on FPD during walking are not well known. ThisExpand
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Suprachiasmatic neuron numbers and rest–activity circadian rhythms in older humans
The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older humans, particularly thoseExpand
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Gut Microbiota is critical for the induction of chemotherapy-induced pain
Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that gut microbiota promotes the development of chemotherapy-induced mechanicalExpand
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Nonlinear Assessment of Cerebral Autoregulation from Spontaneous Blood Pressure and Cerebral Blood Flow Fluctuations
Cerebral autoregulation (CA) is an most important mechanism responsible for the relatively constant blood flow supply to brain when cerebral perfusion pressure varies. Its assessment in nonacuteExpand
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Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice
Significance Healthy systems are characterized by scale invariance across multiple timescales. We investigated whether loss of scale invariance that occurs with aging and disease can be counteractedExpand
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