• Publications
  • Influence
Ciprofloxacin as Ocular Liposomal Hydrogel
  • K. Hosny
  • Chemistry, Medicine
  • AAPS PharmSciTech
  • 12 February 2010
TLDR
It is suggested that the degree of encapsulation of ciprofloxacin into liposomes and prolonged in vitro release depend on composition of the vesicles and the polymer hydrogel used in preparation ensure steady and prolonged transcorneal permeation. Expand
Miconazole-loaded solid lipid nanoparticles: formulation and evaluation of a novel formula with high bioavailability and antifungal activity
  • B. Aljaeid, K. Hosny
  • Materials Science, Medicine
  • International journal of nanomedicine
  • 25 January 2016
TLDR
Miconazole-loaded solid lipid nanoparticles (MN-SLNs) formulated and evaluated for oral administration were more efficient in the treatment of candidiasis with enhanced oral bioavailability and could be a promising carrier for the oral delivery of miconazoles. Expand
The formulation of a nasal nanoemulsion zaleplon in situ gel for the treatment of insomnia
  • K. Hosny, Z. Banjar
  • Materials Science, Medicine
  • Expert opinion on drug delivery
  • 18 July 2013
TLDR
The nasal NEG is a promising novel formula for zaleplon that has higher nasal tissue permeability and enhanced systemic bioavailability. Expand
Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: preparation, characterization, and in vivo evaluation.
TLDR
It can be concluded that the nasal NEG is a promising novel formula for (SM) that has higher nasal tissue permeability and enhanced systemic bioavailability. Expand
Sildenafil citrate as oral solid lipid nanoparticles: a novel formula with higher bioavailability and sustained action for treatment of erectile dysfunction
  • K. Hosny, B. Aljaeid
  • Materials Science, Medicine
  • Expert opinion on drug delivery
  • 18 June 2014
TLDR
SLN could be a promising carrier for sustained/prolonged sildenafil citrate release with enhanced oral bioavailability and in vitro drug release, stability and in vivo pharmacokinetics were studied. Expand
Optimization of caseinate-coated simvastatin-zein nanoparticles: improved bioavailability and modified release characteristics
TLDR
Formulation of caseinate-coated SMV-zein nanoparticles improves the pharmacokinetic profile and bioavailability of SMV and improves hypolipidemic activities for longer duration, in addition to reducing the reduced dosage rate of SMVs improves patient tolerability and compliance. Expand
Chitosan-based Floating Microspheres of Trimetazidin Dihydrochloride; Preparation and In vitro Characterization
TLDR
The prepared floating microspheres may prove to be potential candidates for multiple-unit delivery devices adaptable to any intragastric conditions as well as in vitro floating characteristics found to be regular in shape and highly porous. Expand
Preparation and Evaluation of Thermosensitive Liposomal Hydrogel for Enhanced Transcorneal Permeation of Ofloxacin
  • K. Hosny
  • Medicine, Chemistry
  • AAPS PharmSciTech
  • 10 November 2009
TLDR
The results suggested that the in situ thermosensitive ofloxacin liposomal hydrogel ensures steady and prolonged transcorneal permeation, which improves the ocular bioavailability, minimizes the need for frequent administration, and decreases the Ocular side effect of ofl Oxacin. Expand
Development and Evaluation of Avanafil Self-nanoemulsifying Drug Delivery System with Rapid Onset of Action and Enhanced Bioavailability
TLDR
Stable AVA (SNEDDS) were successfully developed with a droplet size range of 65 to 190 nm and in vivo pharmacokinetic showed a significant increase in Cmax, reduction in Tmax, and SNEDDS enhanced the bioavailability in the rats by 1.4-fold when compared with pure drug. Expand
Optimization of gatifloxacin liposomal hydrogel for enhanced transcorneal permeation
  • K. Hosny
  • Materials Science, Medicine
  • Journal of liposome research
  • 22 June 2009
TLDR
It is suggested that the encapsulation of gatifloxacin into liposomes prolonged the in vitro release, depending on composition of the vesicles, and the polymer hydrogel used in the preparation ensured steady, prolonged transcorneal permeation. Expand
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