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MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.
In search of antiinflammatory drugs with a new mechanism of action, U0126 was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificityExpand
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Functional dissection of a cell-division inhibitor, SulA, of Escherichia coli and its negative regulation by Lon
Abstract SulA is induced in Escherichia coli by the SOS response and inhibits cell division through interaction with FtsZ. To determine which region of SulA is essential for the inhibition of cellExpand
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The functional origin of bacteriophage f1 DNA replication. Its signals and domains.
The origin of DNA replication of bacteriophage f1 functions as a signal, not only for initiation of viral strand synthesis, but also for its termination. Viral (plus) strand synthesis initiates andExpand
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Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate synthase activity in Escherichia coli.
The molecular cloning and the determination of the nucleotide sequence of the ispA gene responsible for farnesyl diphosphate (FPP) synthase [EC 2.5.1.1] activity in Escherichia coli are described. E.Expand
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Osmoregulation of the fatty acid receptor gene fadL in Escherichia coli
The fadL gene of Escherichia coli codes for an outer membrane protein that is involved in the uptake of long-chain fatty acids. Uptake is regulated by environmental osmolarity, and decreases when theExpand
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Disruption of the structural gene for farnesyl diphosphate synthase in Escherichia coli.
The chromosomal ispA gene encoding farnesyl diphosphate synthase of Escherichia coli was disrupted by inserting a neo gene cassette. The null ispA mutants were viable. The growth yield of the mutantsExpand
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Cleavage of Bacteriophage f1 DNA by the Restriction Enzyme of Escherichia coli B
We studied the cleavage of the replicative-form DNA (RF I) of bacteriophage f1 and its SB mutants by purified restriction endonuclease of E. coli B. The results indicate that: (i) CircularExpand
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Structure and expression of mouse apolipoprotein E gene.
The mouse apolipoprotein E gene was isolated from a genomic library by screening with a cDNA probe. DNA including apolipoprotein E gene plus segments 2.5 kilobases upstream and 0.3 kilobaseExpand
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Nucleotide sequence of the primer RNA for DNA replication of filamentous bacteriophages.
We determined the nucleotide sequence of RNA synthesized in vitro by Escherichia coli RNA polymerase at the complementary-strand replication origin on the single-stranded viral DNA of bacteriophagesExpand
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Use of phosph-cellulose paper disks for the assay of histone acetyltransferase.
Abstract A modified method for the assay of histone acetyltransferase is presented. Previously reported methods depended upon the determination of the incorporation of radioactivity from [ 14Expand
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