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Characterization of β-catenin expression in canine osteosarcoma.
Osteosarcoma (OSA) is the most frequently occurring malignant primary bone tumour in dogs and children and arises from cells of the osteoblast lineage. Inappropriate Wnt signalling activity has beenExpand
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Direct delivery of MIF morpholinos into the zebrafish otocyst by injection and electroporation affects inner ear development.
In recent years, electroporation has become a popular technique for in vivo transfection of DNA, RNA, and morpholinos into various tissues, including the eye, brain, and somites of zebrafish. TheExpand
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Effect of mutant β‐catenin on liver growth homeostasis and hepatocarcinogenesis in transgenic mice
Background: Mutations in the Wnt signalling pathway molecule β‐catenin are associated with liver cancer.
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Canine osteosarcoma cell lines from patients with differing serum alkaline phosphatase concentrations display no behavioural differences in vitro.
Osteosarcoma is an aggressive malignancy and represents the most frequent primary bone malignancy of dogs and humans. Prognostic factors reported for osteosarcoma include tumour size, presence ofExpand
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Tumourigenic canine osteosarcoma cell lines associated with frizzled‐6 up‐regulation and enhanced side population cell frequency
An increased serum alkaline phosphatase concentration is known to be associated with a negative prognosis in canine and human osteosarcoma. To expand upon previous studies regarding the biologicalExpand
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Osteosarcoma tissues and cell lines from patients with differing serum alkaline phosphatase concentrations display minimal differences in gene expression patterns.
Serum alkaline phosphatase (ALP) concentration is a prognostic factor for osteosarcoma in multiple studies, although its biological significance remains incompletely understood. To determine whetherExpand
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c-Myc and transforming growth factor α enhance the development of hepatic lesions due to mutant β-catenin in transgenic mice.
Alterations in the Wnt signaling pathway are associated with diverse cancers, including hepatocellular carcinoma (HCC). The development of HCC is thought to be a multistage process in which multipleExpand