Share This Author
Inhibition of death receptor signals by cellular FLIP
The characterization of an inhibitor of apoptosis is reported, designated FLIP (for FLICE-inhibitory protein), which is predominantly expressed in muscle and lymphoid tissues and may be implicated in tissue homeostasis as an important regulator of apoptotic regulation.
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Cardif is described, a new CARD-containing adaptor protein that interacts with RIG-I and recruits IKKα, IKKβ and IKKɛ kinases by means of its C-terminal region, leading to the activation of NF-κB and IRF3.
SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box
The PROSITE database, its status in 1997
The PROSITE database (http://www.expasy.ch/sprot/prosite.htm l) consists of biologically significant patterns and profiles formulated in such a way that with appropriate computational tools it can…
Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair
Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis
The identification of two ubiquitin (Ub)–binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family TLS polymerases (pols), indicate that Ub-binding domains of Y- family polymerases play crucial regulatory roles in TLS.
Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
It is proposed that Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles.
BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth
A novel member of the T NF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells is described, suggesting that BAFF plays an important role as costimulator of B cell proliferation and function.
The PROSITE database, its status in 1999
The PROSITE database consists of biologically significant patterns and profiles formulated in such a way that with appropriate computational tools it can help to determine to which known family of…