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Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients.
- K. Hoffmann, C. Kerner, +4 authors H. Witzigmann
- World journal of gastroenterology
- 14 January 2007
AIM To evaluate the diagnostic potential of cytokeratin-19 (CK-19) mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal… Expand
Melatonin promotes sorafenib‐induced apoptosis through synergistic activation of JNK/c‐jun pathway in human hepatocellular carcinoma
- S. Lin, K. Hoffmann, Chao Gao, Marius Petrulionis, I. Herr, P. Schemmer
- Chemistry, Medicine
- Journal of pineal research
- 1 April 2017
Melatonin has been shown to exert anticancer activity on hepatocellular carcinoma (HCC) through its antiproliferative and pro‐apoptotic effect in both experimental and clinical studies, and sorafenib… Expand
Open-label, multicenter, randomized phase III trial of adjuvant chemoradiation plus interferon Alfa-2b versus fluorouracil and folinic acid for patients with resected pancreatic adenocarcinoma.
- J. Schmidt, U. Abel, +10 authors M. Büchler
- Journal of clinical oncology : official journal…
- 20 November 2012
PURPOSE Adjuvant chemotherapy prolongs survival in patients with pancreatic cancer, but its benefit is limited. Long-term survival times of up to 44 months after adjuvant chemoradioimmunotherapy in… Expand
Supplementation of amino acids to prevent reperfusion injury after liver surgery and transplantation--where do we stand today?
BACKGROUND & AIMS Functional liver failure remains one of the major complications after liver surgery. Ischemia/reperfusion injury (IRI) is strongly associated with increased morbidity and mortality… Expand
Involvement of the epidermal growth factor receptor in the modulation of multidrug resistance in human hepatocellular carcinoma cells in vitro
BackgroundHepatocellular carcinoma (HCC) is a molecular complex tumor with high intrinsic drug resistance. Recent evidence suggests an involvement of the tyrosine kinase pathway in the regulation of… Expand
Prospective, randomized, double-blind, multi-center, Phase III clinical study on transarterial chemoembolization (TACE) combined with Sorafenib® versus TACE plus placebo in patients with…
BackgroundDisease progression of hepatocellular cancer (HCC) in patients eligible for liver transplantation (LTx) occurs in up to 50% of patients, resulting in withdrawal from the LTx waiting list.… Expand
Stroke MRI in Intracerebral Hemorrhage: Is There a Perihemorrhagic Penumbra?
Background and Purpose— Cerebral ischemia has been proposed as a contributing mechanism to secondary neuronal injury after intracerebral hemorrhage (ICH). The search for surrogate parameters that… Expand
Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF‐kB and apoptosis after experimental kidney transplantation
Abstract: Free radicals are involved in pathophysiology of ischemia/reperfusion injury (IRI). Melatonin is a potent scavenger of reactive oxygen and nitrogen species. Thus, this study was designed… Expand
A case of palytoxin poisoning due to contact with zoanthid corals through a skin injury.
- K. Hoffmann, M. Hermanns-Clausen, +4 authors S. Kauferstein
- Toxicon : official journal of the International…
- 15 June 2008
A case of human poisoning by palytoxin after contact with zoanthid corals (Parazoanthus sp.) in an aquarium through skin injuries on fingers is reported. The clinical symptoms include swelling,… Expand
Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation
- R. Liang, A. Nickkholgh, +6 authors P. Schemmer
- Biology, Medicine
- Journal of pineal research
- 1 January 2009
Abstract: Reactive oxygen species (ROS) are involved in pathophysiology of ischemia/reperfusion injury. Melatonin is a potent scavenger of ROS. Thus, this study was designed to elucidate its effects… Expand