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A receptor subtype involved in neuropeptide-Y-induced food intake
The expression cloning of a novel Y-type receptor from rat hypothalamus is reported, which is thought to be the postulated 'feeding' receptor and may provide a new method for the study and treatment of obesity and eating disorders. Expand
The obesity epidemic: current and future pharmacological treatments.
The efficacy of antiobesity agents and their value in the treatment of obesity are assessed in comparison with other therapeutic approaches, such as surgery and changes in lifestyle. Expand
Effects of a specific and long-acting renin inhibitor in the marmoset.
A maximum hypotensive response to CGP 29 287 was associated with complete inhibition of plasma renin activity, and the recovery of blood pressure was accompanied by recovery of plasmarenin activity. Expand
Inhibition of Food Intake by Neuropeptide Y Y5 Receptor Antisense Oligodeoxynucleotides
Analysis of the structure of feeding behavior revealed that prepro NPY and Y5 receptor antisense ODNs reduced food intake by inducing decreases in meal size and meal duration analogous to the orexigenic effects of NPY that are mediated by increases in these parameters. Expand
No Evidence for Product Inhibition of the Renin‐Angiotensinogen Reaction in the Rat
The des-AI-substrate had no inhibitory effect on the reaction of partially purified rat renin with rat angiotensinogen at concentrations corresponding to 0.225 or 0.45 μM angiotENSinogen. Expand
Inhibitors of renin as potential therapeutic agents.
Peripheral Administration of a Melanocortin 4-Receptor Inverse Agonist Prevents Loss of Lean Body Mass in Tumor-Bearing Mice
The view that MC4-R blockade may be a suitable approach for the treatment of cancer cachexia and that MC 4-R inverse agonists may have potential as drug candidates is supported. Expand
Melanocortin‐4 Receptor Activation Stimulates Hypothalamic Brain‐Derived Neurotrophic Factor Release to Regulate Food Intake, Body Temperature and Cardiovascular Function
Results show that BDNF is an important downstream mediator of the MC4R pathway, and demonstrate for the first time that activation ofMC4R leads to an acute release of BDNF in the hypothalamus. Expand
Antibodies raised against different extracellular loops of the melanocortin-3 receptor affect energy balance and autonomic function in rats
Results show that immunization against the MC3R resulted in the production of Abs with positive or negative allosteric properties, and the presence of such Abs induced small changes in metabolic and cardiovascular parameters. Expand
Does vasopressin sustain blood pressure of normally hydrated healthy volunteers?
It is concluded that circulating vasopressin, even in the face of a blocked renin-angiotensin system, does not actively contribute to maintenance of cardiovascular homeostasis. Expand