Skip to search formSkip to main contentSkip to account menu
Small Molecules in Development for the Treatment of Spinal Muscular Atrophy.
TLDR
Both repurposed drugs and small-molecule compounds discovered following medicinal chemistry optimization for the potential treatment of SMA are reviewed.
View on PubMed
Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease
Takahashi et al. demonstrate that restoring glial glutamate transporter EAAT2 function improves cognitive functions and synaptic integrity while reducing amyloid plaques in a sustained fashion after…
View PDF
Barcoded viral tracing of single-cell interactions in central nervous system inflammation
TLDR
RABID-seq identified the axon guidance molecules Sema4D-PlexinB2 and EphrinB3-EphB3 as mediators of microglia-astrocyte interactions that promote CNS pathology in experimental autoimmune encephalomyelitis and, potentially, multiple sclerosis.
View on Publisher
trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents.
The dopaminergic receptor profile of a series of trans-1-[(2-phenylcyclopropyl)methyl]-4-arylpiperazines was examined. Aromatic substitution patterns were varied with the goal of identifying a…
View on PubMed
Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.
TLDR
This series post-translationally stabilizes the SMN protein, unrelated to global proteasome or autophagy inhibition, revealing a novel therapeutic mechanism that should complement other modalities for treatment of SMA.
View on PubMed
The Role of Fluorine in the Discovery and Optimization of CNS Agents: Modulation of Drug-Like Properties
View via Publisher
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
TLDR
The design and synthesis of a series of novel TRPV1 antagonists with a variety of different 6,6-heterocyclic cores is described, and an extensive evaluation of the pharmacological and pharmacokinetic properties of a number of these compounds is reported.
View on PubMed
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.
View on PubMed
CLEAVAGE OR ACETYL-DE-ALKYLATION OF 4-METHOXYBENZYL (MPM)ETHERS USING ACETIC ACID
Abstract Aryl (4-methoxyphenyl)methyl (MPM) ethers are cleaved by heating with acetic acid for a few hours at 90°C, producing the corresponding phenols and (4-methoxyphenyl)methyl acetate. Under the…
View via Publisher
Inter- and intramolecular Mitsunobu reaction based approaches to 2-substituted chromans and chroman-4-ones
View via Publisher
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License