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Small Molecules in Development for the Treatment of Spinal Muscular Atrophy.
- Alyssa N Calder, E. Androphy, K. Hodgetts
- BiologyJournal of medicinal chemistry
- 1 August 2016
TLDR
Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease
- Kou Takahashi, Q. Kong, C. Lin
- BiologyThe Journal of experimental medicine
- 9 March 2015
Takahashi et al. demonstrate that restoring glial glutamate transporter EAAT2 function improves cognitive functions and synaptic integrity while reducing amyloid plaques in a sustained fashion after…
Barcoded viral tracing of single-cell interactions in central nervous system inflammation
- I. Clark, Cristina Gutiérrez-Vázquez, F. Quintana
- BiologyScience
- 23 April 2021
TLDR
trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents.
- X. Zhang, K. Hodgetts, A. Thurkauf
- Chemistry, PsychologyJournal of medicinal chemistry
- 30 September 2000
The dopaminergic receptor profile of a series of trans-1-[(2-phenylcyclopropyl)methyl]-4-arylpiperazines was examined. Aromatic substitution patterns were varied with the goal of identifying a…
Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.
- A. Rietz, Hongxia Li, K. Hodgetts
- BiologyJournal of medicinal chemistry
- 19 May 2017
TLDR
The Role of Fluorine in the Discovery and Optimization of CNS Agents: Modulation of Drug-Like Properties
- K. Hodgetts, K. Combs, A. Elder, G. Harriman
- Biology, Chemistry
- 2010
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
- C. A. Blum, T. Caldwell, K. Hodgetts
- Biology, ChemistryJournal of medicinal chemistry
- 22 March 2010
TLDR
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.
- He Zhao, A. Thurkauf, J. Wasley
- ChemistryBioorganic & medicinal chemistry letters
- 4 November 2002
CLEAVAGE OR ACETYL-DE-ALKYLATION OF 4-METHOXYBENZYL (MPM)ETHERS USING ACETIC ACID
- K. Hodgetts, T. Wallace
- Chemistry
- 1 April 1994
Abstract Aryl (4-methoxyphenyl)methyl (MPM) ethers are cleaved by heating with acetic acid for a few hours at 90°C, producing the corresponding phenols and (4-methoxyphenyl)methyl acetate. Under the…
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