A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
The results show that the biological potency and epigenetic state of in-vitro-reprogrammed induced pluripotent stem cells are indistinguishable from those of ES cells.
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.
Disease-Specific Induced Pluripotent Stem Cells
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse.
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.
Efficient method to generate single‐copy transgenic mice by site‐specific integration in embryonic stem cells
A transgene integration strategy mediated by site‐specific recombination that allows establishment of multiple embryonic stem cell lines carrying tetracycline‐inducible genes targeted to a specific locus to assure predictable temporal and spatial expression in ES cells and mice is described.
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
Overall messenger RNA and microRNA expression patterns are indistinguishable with the exception of a few transcripts encoded within the imprinted Dlk1–Dio3 gene cluster on chromosome 12qF1, which were aberrantly silenced in most of the iPSC clones.
The sox family of transcription factors: versatile regulators of stem and progenitor cell fate.