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Increased interleukin-17 production in patients with systemic sclerosis.
IL-17 overproduction plays an important role in the pathogenesis of SSc, especially in the early stages of the disease, by inducing the proliferation of fibroblasts and the production of IL-1 and the expression of adhesion molecules on endothelial cells.
C-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinoma SAS-H1 cells.
Close association between Streptococcus sobrinus in the saliva of young children and smooth-surface caries increment.
The prevalence of S. sobrinus in saliva was more closely associated with future caries activity, especially with smooth-surface caries increment, than the prevalence of M. mutans or mutants.
Porphyromonas gingivalis Modulates the Production of Interleukin 8 and Monocyte Chemotactic Protein 1 in Human Vascular Endothelial Cells
- Michiyo Kobayashi-Sakamoto, E. Isogai, K. Hirose
- Biology, MedicineCurrent Microbiology
- 1 February 2003
Results indicate that P. gingivalis proteases degraded IL-8 and MCP-1, and N-a-p-tosyl-L-lysine chloromethylketone (TLCK) prevented the degradation of these chemokines.
Osteoprotegerin protects endothelial cells against apoptotic cell death induced by Porphyromonas gingivalis cysteine proteinases.
- Michiyo Kobayashi-Sakamoto, K. Hirose, M. Nishikata, E. Isogai, I. Chiba
- Medicine, BiologyFEMS microbiology letters
- 1 November 2006
Pretreatment of HMVEC with osteoprotegerin reduced the extent of both cellular detachment and apoptotic cell death induced by gingipain-active bacterial cell extracts, suggesting that osteopritegerin may function as a survival factor for endothelial cells during periodontitis.
Bacteroides (Porphyromonas) gingivalis fimbriae activate mouse peritoneal macrophages and induce gene expression and production of interleukin-1
Observations suggest that B. gingivalis fimbriae may be involved in the pathogenesis of adult periodontal disease via triggering of IL-1 production by monocytes/macrophage activation of peritoneal macrophages inperiodontal diseases.
Evaluation of chewing activity in the elderly person.
- H. Miura, Y. Araki, T. Hirai, E. Isogai, K. Hirose, T. Umenai
- Medicine, PsychologyJournal of oral rehabilitation
- 1 March 1998
The mastication score showed significant correlation with other masticatory functions such as maximum biting force, occlusal contact area and the number of missing teeth (P < 0.01).
Bacteroides gingivalis fimbriae stimulate production of thymocyte-activating factor by human gingival fibroblasts
- S. Hanazawa, K. Hirose, Y. Ohmori, S. Amano, S. Kitano
- Biology, MedicineInfection and immunity
- 1 January 1988
It is shown here that the fimbriae bind to the cells, which may subsequently lead to the stimulation of FTAF production by the cells.
NF-kappaB-dependent induction of osteoprotegerin by Porphyromonas gingivalis in endothelial cells.
Inducing effect of periodontopathic bacteria on interleukin-1 production by mouse peritoneal macrophages.
Sonicated extracts from Bacteroides gingivalis. Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, and Actinomyces viscosus were found to strongly induce IL-1 production by mouse…