K. Higashiura

Publications75
h-index24
Citations2,192
Highly Influential Citations31
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Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension
Abstract—Adiponectin, an adipocyte-derived protein, has been suggested to play an important role in insulin sensitivity. We examined the association between insulin sensitivity (M value) evaluated by… Expand
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Effects of angiotensin receptor antagonist and angiotensin converting enzyme inhibitor on insulin sensitivity in fructose-fed hypertensive rats and essential hypertensives.
This study was designed to investigate the effects of angiotensin II (AII) receptor antagonist and angiotensin converting enzyme (ACE) inhibitor on insulin resistance, and the mechanism by which ACE… Expand
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Blockade of the renin–angiotensin system decreases adipocyte size with improvement in insulin sensitivity
Objective Based on results of in vitro studies, it has been hypothesized that blockade of the renin–angiotensin system (RAS) promotes the recruitment and differentiation of pre-adipocytes and that… Expand
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The effects of an angiotensin-converting enzyme inhibitor and an angiotensin II receptor antagonist on insulin resistance in fructose-fed rats.
The aim of this study was to compare the effects of an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II receptor (AT) antagonist on insulin resistance, especially on muscle fiber… Expand
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Chinese medicine, Jiang-Tang-Ke-Li, improves insulin resistance by modulating muscle fiber composition and muscle tumor necrosis factor-alpha in fructose-fed rats.
Insulin resistance and hyperinsulinemia are common findings in patients with essential hypertension. These impairments in glucose metabolism are commonly associated with diabetes mellitus,… Expand
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High plasma immunoreactive leptin level in essential hypertension.
Insulin resistance, the most important factor in metabolic syndrome X, has been considered to raise blood pressure. Recently it was reported that insulin resistance was related to an elevated plasma… Expand
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The contribution of skeletal muscle tumor necrosis factor‐α to insulin resistance and hypertension in fructose‐fed rats
Objective The aim of this study was to determine the role of tumor necrosis factor-α (TNF-α) in skeletal muscle tissue in insulin resistance and hypertension and the effect of anti-hypertensive… Expand
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Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle.
We investigated the effect of fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, on insulin sensitivity including lipid metabolism in skeletal muscle. Six-week-old male… Expand
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Correlations of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations
objective  Adiponectin, which is secreted specifically by adipose tissue, has been shown to have an anti‐atherosclerotic effect and to improve insulin resistance. The aim of this study was to… Expand
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Does insulin resistance participate in an impaired glucose tolerance in primary aldosteronism?
It has been reported that glucose intolerance is occasionally found in primary aldosteronism. In this study, we measured insulin sensitivity by the euglycaemic hyperinsulinaemic glucose clamp… Expand
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