Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension
- M. Furuhashi, N. Ura, K. Shimamoto
- MedicineHYPERTENSION
- 1 July 2003
It is suggested that hypoadiponectinemia is related to insulin resistance in essential hypertension and that RAS blockade increases adiponectin concentrations with improvement in insulin sensitivity.
Blockade of the renin–angiotensin system decreases adipocyte size with improvement in insulin sensitivity
- M. Furuhashi, N. Ura, K. Shimamoto
- Medicine, BiologyJournal of Hypertension
- 1 October 2004
RAS blockade decreases adipocyte size without change in epididymal %fat pads accompanied by improvement in insulin sensitivity, thereby improving insulin sensitivity in fructose-fed rats as a model of insulin-resistant hypertension.
Effects of angiotensin receptor antagonist and angiotensin converting enzyme inhibitor on insulin sensitivity in fructose-fed hypertensive rats and essential hypertensives.
- O. Iimura, K. Shimamoto, M. Nakagawa
- MedicineAmerican Journal of Hypertension
- 1 April 1995
The effects of an angiotensin-converting enzyme inhibitor and an angiotensin II receptor antagonist on insulin resistance in fructose-fed rats.
- K. Higashiura, N. Ura, K. Shimamoto
- Biology, MedicineAmerican Journal of Hypertension
- 1 March 2000
The contribution of skeletal muscle tumor necrosis factor‐α to insulin resistance and hypertension in fructose‐fed rats
- N. Togashi, N. Ura, K. Higashiura, H. Murakami, K. Shimamoto
- Biology, MedicineJournal of Hypertension
- 1 November 2000
The results suggest that skeletal muscle TNF-α is linked to insulin resistance and hypertension and that angiotensin II may be one of the factors that regulate skeletal Muscle necrosis factor-α.
Chinese medicine, Jiang-Tang-Ke-Li, improves insulin resistance by modulating muscle fiber composition and muscle tumor necrosis factor-alpha in fructose-fed rats.
- Ling Wang, K. Higashiura, N. Ura, T. Miura, K. Shimamoto
- Medicine, BiologyHypertension Research
- 1 July 2003
The results suggest that the Chinese medicine JTKL, which contains PG as one of its valid components, improves insulin resistance by modulating muscle fiber composition and TNF-alpha in skeletal muscles in hypertensive and insulin-resistant FFR.
High plasma immunoreactive leptin level in essential hypertension.
- J. Agata, A. Masuda, K. Shimamoto
- Medicine, BiologyAmerican Journal of Hypertension
- 1 October 1997
Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle.
- M. Furuhashi, N. Ura, K. Shimamoto
- BiologyJournal of Endocrinology
- 1 August 2002
Fenofibrate improves insulin sensitivity not only by lowering serum lipids and subsequent influx of fatty acids into muscles but also by reducing intramuscular lipid content via further induction of FABP and stimulation of beta-oxidation in muscles.
Correlations of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations
- K. Higashiura, N. Ura, K. Shimamoto
- MedicineClinical Endocrinology
- 1 December 2004
Adiponectin, which is secreted specifically by adipose tissue, has been shown to have an anti‐atherosclerotic effect and to improve insulin resistance and atherosclerosis.
Characterization of the cloned HEL cell thromboxane A2 receptor: evidence that the affinity state can be altered by G alpha 13 and G alpha q.
- C. J. Allan, K. Higashiura, P. Halushka
- BiologyJournal of Pharmacology and Experimental…
- 1 May 1996
The cloned HEL cell TXA2 receptor has pharmacological characteristics of a low affinity platelet type receptor and the affinity state of this receptor may be influenced by interaction with G alpha 13 and G alpha q.
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