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New genetic loci link adipose and insulin biology to body fat distribution

A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

A mendelian randomization study based on data from multiple cohorts conducted by Karani Santhanakrishnan Vimaleswaran and colleagues re-examines the causal nature of the relationship between vitamin…
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

A meta-analysis of genome-wide association studies for WHR adjusted for body mass index provides evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?

The data suggest that the effects of exercise on FNDC5 and irisin are not consistent, and that their role in health is questionable, and the regulatory mechanisms should be studied further.
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Viscosity of oat bran-enriched beverages influences gastrointestinal hormonal responses in healthy humans.

Viscous fibers, including beta-glucan in oat bran, favorably affect satiety as well as postprandial carbohydrate and lipid metabolism. However, effects of fiber viscosity on modulation of…
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Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding

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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

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Characteristics and significance of colorectal cancer associated lymphoid reaction

It is suggested that CLR contributes to the adaptive antitumor immunity in CRC and had prognostic value that was independent of stage, Klintrup‐Mäkinen score for peritumoral inflammation and the numbers of tumor infiltrating T cells.
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Effect of protein, fat, carbohydrate and fibre on gastrointestinal peptide release in humans

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Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma

Serum cytokine profile shows promise in separating CRC patients from healthy controls but its clinical value is yet to be confirmed, highlighting the importance of studying relative cytokine level alterations.
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