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The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma.
Blinded studies on sera from postmenopausal patients with ovarian carcinoma and controls indicate that the specificity and sensitivity of the HE4-based ELISA is equivalent to that of the CA125 assay, however, the He4 assay may have an advantage over theCA125 assay in that it is less frequently positive in patients with nonmalignant disease. Expand
Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity
Results show that tumor immunogenicity is critical to the outcome of costimulation of T cell-mediated tumor immunity by B7, and immunization with B7-transduced immunogenic tumors enhanced protective immunity and increased specific cytotoxic T lymphocyte activity against the respective wild-type tumors. Expand
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
It is shown that administration of anti-4-1BB monoclonal antibodies can eradicate established large tumors in mice, including the poorly immunogenic Ag104A sarcoma and the highly tumorigenic P815 masto cytoma, and the data suggest that a similar approach may be efficacious for immunotherapy of human cancer. Expand
Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma.
A new member of the mesothelin/MPF family was discovered, which has an 82-bp insert in the membrane-associated part, leading to a frameshift of 212 bp, and whose predicted molecular structure indicates that it is soluble. Expand
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
It is suggested that increasing T cell costimulation through the CD28 and CTLA-4 receptors may have therapeutic usefulness for generating immunity against tumors expressing viral antigens. Expand
Quantitative analysis of melanoma-associated antigen p97 in normal and neoplastic tissues.
It is concluded that monoclonal antibodies to p97 may prove to be of value for the diagnosis and therapy of melanoma. Expand
Cell Surface Antigens of Human Melanoma
Monoclonal antibodies to seven cell surface antigens of human melanoma are obtained, of great interest, because of their potential value in diagnosis and therapy. Expand
Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates.
BR96-DOX induced complete regressions and cures of xenografted human lung, breast, and colon carcinomas growing subcutaneously in athymic mice and cured 70 percent of mice bearing extensive metastases of a human lung carcinoma. Expand
Highly tumor-reactive, internalizing, mouse monoclonal antibodies to Le(y)-related cell surface antigens.
Two monoclonal antibodies, designated BR64 (IgG1) and BR96 (IgG3), were generated that, according to immunohistology, bind selectively to carcinomas of the colon, breast, ovary, and lung. They haveExpand
Human melanoma-associated antigen p97 is structurally and functionally related to transferrin
The purification of p97 by affinity chromatography with monoclonal antibody, followed by SDS-polyacrylamide gel electrophoresis (SDS-PAGE), and determination of the N-terminal amino acid sequence using a new, highly sensitive protein sequencer found the sequence to be homologous to the N -terminal sequences of transferrin and lactotransferrin. Expand