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Recent advances in Annonaceous acetogenins.
Hough most acetogenins have high potencies among several solid human tumour cells lines, some of the derivatives within the different structural types and some positional isomers show remarkable selectivities among certain cell lines, e.g. against prostate cancer (PC-3).
Bioactive compounds from Taiwania cryptomerioides.
Bioactivities of the isolated compounds against brine shrimp, yellow fever mosquito larvae, and human tumor cells are reported; compound 4 was the most bioactive, showing selectivity for the human colon tumor cell line (HT-29).
UFLC/MS-IT-TOF guided isolation of anti-HBV active chlorogenic acid analogues from Artemisia capillaris as a traditional Chinese herb for the treatment of hepatitis.
The results of this investigation support the ethnopharmacological use of Artemisia capillaris as anti-HBV agents and show that carboxyl group is closely associated to the anti- HBV activity.
Applying Mosher's method to acetogenins bearing vicinal diols. The absolute configurations of muricatetrocin C and rollidecins A and B, new bioactive acetogenins from Rollinia mucosa.
Three new bioactive annonaceous acetogenins bearing vicinal diols isolated from the leaves of Rollinia mucosa showed potent and selective inhibitory effects against several human cancer cell lines.
Additional bioactive annonaceous acetogenins from Asimina triloba (Annonaceae).
Bioactivities of these new structures against brine shrimp larvae and six human solid tumor cell lines were determined, and cytotoxic selectivities were shown for the lung and breast cell lines with up to a million times the potency of adriamycin.
Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris.
Twenty-five compounds possessed inhibitory activity against HBV DNA replication according to the anti-HBV assay on HepG 2.15 cell line in vitro and the most active compound 12 could inhibit not only the secretions of HBsAg and HBeAg, but also HBVDNA replication.
Six indole alkaloids were isolated from Aristotelia chilensis. 2-epi-Aristotelone, only known as a synthetic product, was found for the first time as a natural product. This compound, as well as
A biflavonoid from Dysoxylum lenticellare gillespie
Abstract A novel biflavonoid, robustaflavone 4′,7″-dimethyl ether, has been isolated from the leaves of Dysoxylum lenticellare , in addition to two known compounds, isoginkgetin and bilobetin. Their
cis-gigantrionenin and 4-acetyl gigantetrocin A, two new bioactive annonaceous acetogenins from Goniothalamus giganteus, and the stereochemistries of acetogenin 1,2,5-triols.
Using activity-directed fractionation, two new bioactive acetogenins, cis-gigantrionenin (1) and 4-acetyl gigantetrocin A (2), have been isolated from the bark of Goniothalamus giganteus