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Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu).
Methylation analyses showed that fucoidan had various sugar linkages, and revealed that thefucoidan might have complicated structure, and showed potent antiviral activities against herpes simplex virus type 1 (HSV-1), HSV-2, and human cytomegalovirus. Expand
Isolation of an antiviral polysaccharide, nostoflan, from a terrestrial cyanobacterium, Nostoc flagelliforme.
Besides anti-HSV-1 activity, nostoflan showed potent antiviral activities against HSV-2, human cytomegalovirus, and influenza A virus, but no activity against adenovirus and coxsackie virus was observed. Expand
Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection.
Results suggested that oral intake of the fucoidan might take the protective effects through direct inhibition of viral replication and stimulation of both innate and adaptive immune defense functions. Expand
In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans.
The results demonstrated that APS might have beneficial therapeutic effects on influenza A virus infection at least in part by modulation of the immune function of macrophages. Expand
Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus.
Arctiin and its aglucone, arctigenin from the fruits of Arctium lappa L. showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). Based on the data fromExpand
Antiviral activity of berberine and related compounds against human cytomegalovirus.
Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis. Expand
Antiherpetic activities of sulfated polysaccharides from green algae.
Results revealed that some sulfated polysaccharides from green algae should be promising candidates of antiviral agents which might act on different stages in the virus replication cycle. Expand
Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay.
A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa, collected in deep sea water from Toyama Bay and showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices of 270, 510 and 32. Expand
Aptamer That Binds to the gD Protein of Herpes Simplex Virus 1 and Efficiently Inhibits Viral Entry
The studies suggest that the mini-1 aptamer could be explored further as an anti-HSV-1 topical therapy designed to prevent the risk of acquiring HSv-1 infection through physical contact. Expand
Lactobacillus plantarum strain YU from fermented foods activates Th1 and protective immune responses.
This strain of Lactobacillus plantarum strain YU (LpYU), which has high interleukin (IL)-12-inducing activity in mouse peritoneal macrophages, has a beneficial effect in activating Th1 immune responses and preventing viral infection. Expand