• Publications
  • Influence
Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis.
It was revealed that Ca-SP selectively inhibited the penetration of virus into host cells, and retention of molecular conformation by chelation of calcium ion with sulfate groups was suggested to be indispensable to its antiviral effect. Expand
A natural sulfated polysaccharide, calcium spirulan, isolated from Spirulina platensis: in vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities.
Ca-SP can be a candidate agent for an anti-HIV therapeutic drug that might overcome the disadvantages observed in many sulfated polysaccharides, because it had very low anticoagulant activity, and showed a much longer half-life in the blood of mice when compared with that of DS. Expand
Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1, influenza virus, and HIV.
These in vitro findings demonstrate that the essential oils provide virucidal activity against enveloped viruses by interfering with the function of virus envelope. Expand
A novel antivirally active fucan sulfate derived from an edible brown alga, Sargassum horneri.
A novel fucan sulfate (Hor-1) was isolated from the hot water extract of an edible brown alga and exhibited inhibitory activity against replication of herpes simplex virus type 1 with similar potency to Na-HOR. Expand
The diagnostic value of bone scan in patients with renal cell carcinoma.
Bone scan may be omitted in patients with stages T1-3aN0M0 tumors and no bone pain because of the low proportion of missed cases with bone metastasis. Expand
Characterization of antiviral activity of a sesquiterpene, triptofordin C-2.
The activities of 13 sesquiterpenes isolated from Tripterygium wilfordii Hook fil. var. regelii Makino were studied against herpes simplex virus type 1 (HSV-1) in vitro. Among these compounds, onlyExpand
An evaluation of Bosniak's radiological classification of cystic renal masses
Objective To determine the clinical usefulness of Bosniak's classification of cystic renal masses, the differentiation of which remains difficult despite significant advances in diagnostic imaging.
Effects of structural modification of calcium spirulan, a sulfated polysaccharide from Spirulina platensis, on antiviral activity.
Replacement of calcium ion with sodium and potassium ions maintained the antiviral activity while divalent and trivalent metal cations reduced the activity. Expand
Evaluation of (1R,2R)-1-(5'-methylfur-3'-yl)propane-1,2,3-triol, a sphydrofuran derivative isolated from a Streptomyces species, as an anti-herpesvirus drug.
The results, taken together, suggest that MFPT might act by limiting the maturation of HSV-specific glycoproteins, particularly of HSv-1 gC. Expand
Further purification and structural analysis of calcium spirulan from Spirulina platensis.
An antiviral sulfated polysaccharide, calcium spirulan (Ca-SP), isolated from Spirulina platensis, was subjected to further purification. Ca-SP was found to be composed of rhamnose,Expand