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Poly(ethylene glycol)-Conjugated PAMAM Dendrimer for Biocompatible, High-Efficiency DNA Delivery
We demonstrate a simple and successful synthetic approach to devise a highly efficient DNA delivery system with low cytotoxicity and low cost. Polyamidoamine (PAMAM) dendrimer is a highly efficient… Expand
Cellular recognition of synthetic peptide amphiphiles in self-assembled monolayer films.
- T. Pakalns, K. Haverstick, G. Fields, J. McCarthy, D. Mooradian, M. Tirrell
- Chemistry, Medicine
- 1 December 1999
The incorporation of lipidated cell adhesion peptides into self-assembled structures such as films provides the opportunity to develop unique biomimetic materials with well-organized interfaces.… Expand
In vitro cytotoxicity and in vivo distribution after direct delivery of PEG-camptothecin conjugates to the rat brain.
Low water solubility and rapid elimination from the brain inhibits local delivery via implants and other delivery systems of most therapeutic drugs to the brain. We have conjugated the chemotherapy… Expand
Efficacy of camptothecin and polymer-conjugated camptothecin in tumor spheroids and solid tumors
- Victoria Ying, K. Haverstick, R. Page, W. Saltzman
- Materials Science, Medicine
- Journal of biomaterials science. Polymer edition
- 1 January 2007
Camptothecin (CPT) is an anti-cancer drug with low solubility in aqueous solutions, which limits its efficacy during chemotherapy. To bypass this problem, CPT was conjugated to poly(ethylene glycol)… Expand
Conjugation to increase treatment volume during local therapy: a case study with PEGylated camptothecin.
Controlled release of chemotherapy drugs from polymer implants placed directly at the tumor site is a proven method for treatment of cancers of the brain. Although this method provides high doses of… Expand
Force Titration of Langmuir-Blodgett Bilayers of Glycine Amphiphiles: JKR-Type Measurements Using the Surface-Force Apparatus
Using the surface-force apparatus, we have made Johnson-Kendall-Roberts (JKR)-type adhesion measurements between Langmuir-Blodgett (LB) bilayers of a novel glycine amphiphile. The bilayers show a… Expand
FORCE AND ADHESION MEASUREMENTS BETWEEN HYDROGEN-BONDED LAYERS OF GLYCINE-FUNCTIONALIZED AMPHIPHILES
James Schneider, Peter Berndt, Kraig Haverstick,Sanjay Kumar, Shiv Chiruvolu, and Matthew Tirrell*Department of Chemical Engineering andMaterials Science, UniVersity of MinnesotaMinneapolis,… Expand
Surface Force Measurements of Electrostatic and Hydrogen-Bonding Interactions between Bilayers of Glycine Amphiphiles
Using the surface-force apparatus (SFA), we have made sensitive force and adhesion measurements between Langmuir-Blodgett (LB) bilayers of a novel glycine-containing amphiphile at various pHs. The… Expand
Fundamental behavior of a model biomolecular amphiphile system
- K. Haverstick
- Materials Science