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Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases. Although numerous probiotic microorganisms have been identified, there remains aExpand
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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induceExpand
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Bifidobacteria can protect from enteropathogenic infection through production of acetate
The human gut is colonized with a wide variety of microorganisms, including species, such as those belonging to the bacterial genus Bifidobacterium, that have beneficial effects on human physiologyExpand
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M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex
Cell–cell communication is essential for the development and homeostasis of multicellular organisms. Recently, a new type of cell–cell communication was discovered that is based on the formation ofExpand
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Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response
The mucosal immune system forms the largest part of the entire immune system, containing about three-quarters of all lymphocytes and producing grams of secretory IgA daily to protect the mucosalExpand
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The microbiota regulates type 2 immunity through RORγt+ T cells
Gut microbes make T cells keep the peace Our guts harbor trillions of microbial inhabitants, some of which regulate the types of immune cells that are present in the gut. For instance, ClostridiumExpand
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A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity
Airway hypersensitive reaction (AHR) is an animal model for asthma, which is caused or enhanced by environmental factors such as allergen exposure. However, the precise mechanisms that drive AHRExpand
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Cell Differentiation Is a Key Determinant of Cathelicidin LL-37/Human Cationic Antimicrobial Protein 18 Expression by Human Colon Epithelium
ABSTRACT Antimicrobial peptides are highly conserved evolutionarily and are thought to play an important role in innate immunity at intestinal mucosal surfaces. To better understand the role of theExpand
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Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori.
BACKGROUND & AIMS LL-37/human cationic antimicrobial peptide 18 (hCAP18) is a human cathelicidin with broad-spectrum antimicrobial, lipopolysaccharide binding, and chemotactic activities. This studyExpand
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Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses
IgM antibodies have been known for decades to enhance humoral immune responses in an antigen-specific fashion. This enhancement has been thought to be dependent on complement activation byExpand
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