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Reduction of proteinuria by therapeutic intervention improves the renal outcome of elderly patients with IgA nephropathy
TLDR
In elderly IgAN patients, the reduction of proteinuria by therapeutic interventions may lead to better renal outcomes without causing severe extrarenal complications.
Effects of pitavastatin add-on therapy on chronic kidney disease with albuminuria and dyslipidemia
TLDR
Although statin add-on therapy did not show additive renal protective effects, the diet therapy as well as the diet-plus-statin therapy could contribute to the reduction in plasma pentosidine in CKD patients with albuminuria and dyslipidemia.
Early Enhanced Leucine-Rich α-2-Glycoprotein-1 Expression in Glomerular Endothelial Cells of Type 2 Diabetic Nephropathy Model Mice
TLDR
It is suggested that leucine-rich α-2-glycoprotein-1 plays a pivotal role in the initial development of diabetic nephropathy by promoting abnormal angiogenesis, thereby suggesting that LRG1 is a potential preemptive therapeutic target of diabetic necrosis.
Improved home BP profile with dapagliflozin is associated with amelioration of albuminuria in Japanese patients with diabetic nephropathy: the Yokohama add-on inhibitory efficacy of dapagliflozin on
TLDR
In Japanese patients with T2DM and diabetic nephropathy, dapagliflozin significantly improved albuminuria levels and the home BP profile, but not with changes in other variables, including office BP.
Glomerulopathy Associated With Moderate Obesity
Single-Nephron GFR in Patients With Obesity-Related Glomerulopathy
Dietary Protein Intake and Single-Nephron Glomerular Filtration Rate
TLDR
It is indicated that greater protein intake may increase SNGFR and lead to glomerular hyperfiltration, and nutritional indices associated with single-nephron GFR calculated based on corrected creatinine clearance were evaluated.
Glomerular Density and Volume in Renal Biopsy Specimens of Children with Proteinuria Relative to Preterm Birth and Gestational Age.
TLDR
A low GD together with marked glomerular enlargement characterizes renal biopsy samples of children born with a LBW at an early stage of gestation and shows close positive correlations with birth weight and gestational age.
Angiotensin II Type 1 Receptor‐Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin
TLDR
Results indicate that ATRAP plays an important role in inhibiting kidney aging, possibly through sirtuin1‐mediated mechanism independent of blocking AT1R signaling, and further protecting normal life span.
Adipocyte‐Specific Enhancement of Angiotensin II Type 1 Receptor‐Associated Protein Ameliorates Diet‐Induced Visceral Obesity and Insulin Resistance
TLDR
It is suggested that the enhancement in adipose ATRAP plays a protective role against the development of diet‐induced visceral obesity and insulin resistance through improvement of adipose inflammation and function via the suppression of overactivation of adiposes AT1R signaling.
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