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Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term…
The results demonstrate that the new series sample method combined with three-dimensional reconstruction reveals quantitative changes in the frequency and structure of spines and synapses that are not discernable by other methods and are likely to have dramatic effects on synaptic physiology and plasticity.
CREB: A Major Mediator of Neuronal Neurotrophin Responses
Balancing structure and function at hippocampal dendritic spines.
Advances in imaging and computing technologies may provide the resources needed to reconstruct entire neural circuits as well as having sufficient resolution to determine the extrinsic factors and the intrinsic factors that are required to build and maintain synapses.
Synaptogenesis Via Dendritic Filopodia in Developing Hippocampal Area CA1
The concurrence of primarily shaft and filopodial synapses in the first postnatal week suggests that Filopodia recruit shaft synapses that later give rise to spines through a process of outgrowth.
Do thin spines learn to be mushroom spines that remember?
Plasticity-Induced Growth of Dendritic Spines by Exocytic Trafficking from Recycling Endosomes
Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function.
The recent conjunction of high quality information about the structure, function, and theoretical implications of dendritic spines has produced a flurry of new insights into the location and function of these tiny protrusions in the CNS.
Three-Dimensional Structure and Composition of CA3→CA1 Axons in Rat Hippocampal Slices: Implications for Presynaptic Connectivity and Compartmentalization
Physiological studies of CA3→CA1 synaptic transmission and plasticity have revealed both pre- and postsynaptic effects. Understanding the extent to which individual presynaptic axonal boutons could…
Three-Dimensional Organization of Smooth Endoplasmic Reticulum in Hippocampal CA1 Dendrites and Dendritic Spines of the Immature and Mature Rat
The hypothesis that the smooth endoplasmic reticulum regulates the ionic and structural milieu of some, but not all, hippocampal dendritic spines is supported.
Three-Dimensional Relationships between Hippocampal Synapses and Astrocytes
Recent studies show that glutamate transporter-mediated currents occur in astrocytes when glutamate is released from hippocampal synapses. These transporters remove excess glutamate from the…