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Suppression of myocardial protein degradation by the protease inhibitor bis[ethyl(2R,3R)-3-[(S)-methyl-1-[4-(2,3,4-tri-methoxy-phenyl-methyl)
TLDR
Data might support the view that NCO-700 sensitive protease(s) - possibly, calcium-activated neutral protease and/or cathepsin B - is (are) working to induce an irreversible proteolysis in the process of myocardial cell degradation. Expand
Orally active factor Xa inhibitors: investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy.
TLDR
A series of novel and potent 3-amidinophenylsulfonamide derivatives of factor Xa inhibitors were designed and synthesized using an amidoxime prodrug strategy, and KFA-1982 was selected for clinical development. Expand
Ca overload and the action of calcium sensitive proteases, phospholipases and prostaglandin E2 in myocardial cell degradation
TLDR
The results suggest that the Ca overdose into the myocardial cells potentiates their injury and it is not primarily related to the activation of CANP, CDP nor cyclooxygenase. Expand
Characteristics of the hemostatic action of KFA-1411, an inhibitor of coagulation factor Xa (FXa), in humans and various animals.
TLDR
Results indicate that KFA-1411 may exhibit antithrombotic efficacy without an unwanted platelet-related action in the future treatment of various thrombosis diseases. Expand
Evaluation of a New Blood Coagulation Factor Xa Inhibitor, KFA-1411, as an Anticoagulant in a Cynomolgus Monkey Hemodialysis Model: Parameters Suitable for Monitoring Anticoagulant Activities
TLDR
Results indicate that this selective FXa inhibitor could be used as an anticoagulant for hemodialysis, and both activated partial thromboplastin time (APTT) and prothrombin time (PT) can be used to monitor the anticoAGulant activity in the extracorporeal circulation. Expand
Prophylactic Effects Of Pilocarpine Hydrochloride On Xerostomia Models Induced By X‐Ray Irradiation In Rats
TLDR
Salivary volume, amylase activity and protein concentration in the saliva secreted from the right parotid gland were measured before and after a subsequent administration of pilocarpine hydrochloride (intraduodenal). Expand
Suppressive effects of the anti-allergic drugs, tranilast and azelastine, on the lysophosphatidylserine-dependent activation of rat mast cells.
TLDR
The findings suggest that tranilast and azelastine inhibit lysoPS-depedent histamine release through essentially different routes. Expand
[Anti-allergic effects of (E)-3-[p-(1H-imidazol-1-lylmethyl) phenyl]-2-propenoic acid (OKY-046), a specific thromboxane (TX) A2 synthetase inhibitor: effects on type I allergic reactions].
TLDR
It is thought that OKY-046 should be an useful asthmatic drug or anti-allergic drug by oral administration and there was no effect of OKy-046 on SRS-A and leukotriene release from actively sensitized guinea pig lungs and passively sensitized rats. Expand
Neutralization of low molecular weight heparin by protamine sulfate
TLDR
The results suggest that the bleeding tendency caused by over-doses of low molecular weight haparin can be specifically prevented by protamine. Expand
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