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Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection
Hepatic steatosis is one of the histopathologic features of chronic hepatitis C. It was reported recently that the expression of hepatitis C virus (HCV) core protein in transgenic mice inducedExpand
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Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44 and p42(*)
Cell adhesion to extracellular matrix proteins is a dynamic process leading to dramatic changes in the cell phenotype. Integrins are one of the major receptor families that mediate cell-matrixExpand
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Different mechanisms for anti-tumor effects of low- and high-dose cyclophosphamide.
It is known that, besides its direct cytotoxic effect as an alkylating chemotherapeutic agent, cyclophosphamide also has immuno-modulatory effects, such as depletion of CD4+CD25+ regulatory T cells.Expand
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  • Open Access
Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus
OBJECTIVES:The role of host genetic factors in chronic hepatitis B virus (HBV) infection is not fully understood. We studied the influence of tumor necrosis factor-α (TNF-α) and interleukin-10Expand
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Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection--association between TGF-beta1 polymorphisms and hepatocellular carcinoma.
BACKGROUND/AIMS In this study, we determined the frequencies of the genotypes associated with the polymorphism of the cytokines genes, and investigated their association with the risk ofExpand
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Activation of caspase‐8 in transforming growth factor‐β–induced apoptosis of human hepatoma cells
Transforming growth factor‐β1 (TGF‐β1) has been shown to induce apoptosis in normal or transformed hepatocytes. To elucidate the biochemical pathways leading to apoptosis induced by TGF‐β1 in humanExpand
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Role of growth hormone, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in development of non-alcoholic fatty liver disease
Background and aimsPituitary dysfunction including growth hormone (GH) deficiency may be associated with non-alcoholic fatty liver disease (NAFLD). Since the relationships among GH, IGF-1, IGFBP-3,Expand
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Aspirin and NS‐398 inhibit hepatocyte growth factor–induced invasiveness of human hepatoma cells
Nonsteroidal anti‐inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and are considered to exert antitumor actions in a variety of cancer cells, although the effects are unlikelyExpand
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Antiangiogenic property of pigment epithelium‐derived factor in hepatocellular carcinoma
Pigment epithelium‐derived factor (PEDF) is one of the most powerful endogenous antiangiogenic reagents discovered to date. Its antiangiogenic potential in neoplastic disease remains unclear. In thisExpand
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Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130Cas.
A novel signaling molecule p130Cas has been shown to undergo tyrosine phosphorylation in response to integrin-mediated cell adhesion. In this study, we have attempted to identify kinases that mediateExpand
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