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Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
It is shown that JNK programs a gene expression pattern in different cell types that cooperatively enhances the degradation of the extracellular matrix while suppressing biosynthetic enzymes of the Extracellular Matrix.
Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease: clinical trial and preliminary results.
This new therapy appears to be safe and could provide a treatment option for patients with otherwise untreatable ischemic heart disease.
Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury.
Various cytokines were produced by BM-MNCs, and these cytokines contributed to functional improvement of the infarcted heart by directly preserving the contractile capacity of the myocardium, inhibiting apoptosis of cardiomyocytes, and inducing therapeutic angiogenesis of the inflamed heart.
Regeneration of Infarcted Myocardium by Intramyocardial Implantation of Ex Vivo Transforming Growth Factor-&bgr;–Preprogrammed Bone Marrow Stem Cells
The intramyocardial implantation of TGF-&bgr;–preprogrammed CD117+ cells effectively assisted the myocardial regeneration and induced therapeutic angiogenesis, contributing to functional cardiac regeneration.
Improved angiogenic potency by implantation of ex vivo hypoxia prestimulated bone marrow cells in rats.
Ex vivo hypoxia stimulation increased the VEGF mRNA expression and endothelial differentiation of bone marrow cells, which together contributed to improved therapeutic angiogenesis in the ischemic hindlimb after implantation.
CD117+ stem cells play a key role in therapeutic angiogenesis induced by bone marrow cell implantation.
CD117+ stem cells play a key role in the therapeutic angiogenesis induced by bone marrow cell implantation, and the angiogenic potency of CD117+ and CD117- cells was investigated in vitro and in vivo.
Significance of ultrasound examination of skin and subcutaneous tissue in secondary lower extremity lymphedema.
Evaluating subcutaneous echogenicity is feasible even with low-resolution ultrasound and reflects the ISL stage, and may thus be valuable to objectively represent the severity of extremity lymphedema.