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Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon‐alpha plus ribavirin combination therapy
Background and Aim:  Combination treatments of interferon‐alpha (IFN) and ribavirin (RBV) are more effective than those of IFN alone in hepatitis C virus (HCV) infection. However, mechanisms of theExpand
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Prospective randomized crossover trial of combination therapy with bezafibrate and UDCA for primary biliary cirrhosis.
The aim of this study was to evaluate the effects of the combination therapy with bezafibrate and ursodeoxycholic acid (UDCA) for primary biliary cirrhosis (PBC), compared to UDCA monotherapy.Expand
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A case of primary leiomyoma of the liver in a patient without evidence of immunosuppression.
A 31-year-old Japanese male was admitted to our hospital for investigation of an asymptomatic nodular lesion of the liver detected by abdominal ultrasonography (US) during a routine medicalExpand
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Interferon-stimulated gene expression and hepatitis C viral dynamics during different interferon regimens.
BACKGROUND/AIMS To address the molecular mechanism for enhanced antiviral efficacy associated with a frequent dosing of interferon (IFN)-beta. METHODS Serum hepatitis C viral (HCV) dynamics,Expand
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Assessment of Kupffer cells by ferumoxides-enhanced MR imaging is beneficial for diagnosis of hepatocellular carcinoma: comparison of pathological diagnosis and perfusion patterns assessed by CT
To investigate the clinical significance of the radiographic assessment of Kupffer cells and hemodynamics in the diagnosis of hepatocellular nodules, both magnetic resonance (MR) imaging enhanced byExpand
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Usefulness of procalcitonin for severity assessment in patients with acute cholangitis.
BACKGROUND The aim of the present study was to examine the usability of procalcitonin (PCT) for severity assessment in patients with acute cholangitis (AC). METHODS Serum PCT concentrations wereExpand
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Changes of HCV quasispecies during combination therapy with interferon and ribavirin.
Treatment of chronic hepatitis C virus (HCV) infection with interferon (IFN) and ribavirin improves the rate of eradication of HCV, but only about 13-14% of non-responders (NR) with HCV of genotypeExpand
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Core promoter/pre-core mutations are associated with lamivudine-induced HBeAg loss in chronic hepatitis B with genotype C.
BACKGROUND/AIMS To clarify the factors associated with the efficacy of lamivudine. METHODS Variables including basic core promoter (BCP) and pre-core (PreC) mutations were evaluated in 60 chronicExpand
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Sequence elements correlating with circulating viral load in genotype 1b hepatitis C virus infection.
The correlation between hepatitis C virus (HCV) genomic sequences and circulating HCV RNA levels was assessed to investigate the genetic elements affecting viral load. The interferonExpand
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[Ulcerative colitis developed after acute exacerbation of chronic hepatitis B].
症例は39歳,男性. B型慢性肝炎の急性増悪のため近医入院.肝不全徴候を認めlamivudine 100mg内服を開始した.投与開始後速やかに肝逸脱酵素は改善し, HBV DNAは感度以下となった.Expand
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