• Publications
  • Influence
The Brain Chondroitin Sulfate Proteoglycan Brevican Associates with Astrocytes Ensheathing Cerebellar Glomeruli and Inhibits Neurite Outgrowth from Granule Neurons
It is suggested that brevican presented on the surface of neuroglial sheaths may be controlling the infiltration of axons and dendrites into maturing glomeruli in brain development. Expand
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.
It is suggested that a primary function of Shp2 in postmitotic forebrain neurons is to control energy balance and metabolism, and that this phosphatase is a critical signaling component of leptin receptor ObRb in the hypothalamus. Expand
Immunohistochemical evidence for the brevican‐tenascin‐R interaction: Colocalization in perineuronal nets suggests a physiological role for the interaction in the adult rat brain
Immunoelectron microscopy identified brevican immunoreactivity in the intercellular spaces surrounding presynaptic boutons and on their surfaces, but not in the synaptic clefts or in their immediate vicinity, a distribution pattern consistent with perineuronal nets. Expand
Deletion of Shp2 in the Brain Leads to Defective Proliferation and Differentiation in Neural Stem Cells and Early Postnatal Lethality
In vitro analyses suggest that Shp2 mediates basic fibroblast growth factor signals in stimulating self-renewing proliferation of NSCs, partly through control of Bmi-1 expression and reciprocal regulation of the Erk and Stat3 signaling pathways. Expand
Glypican‐4 is an FGF2‐binding heparan sulfate proteoglycan expressed in neural precursor cells
Data is presented indicating that glypican‐4 (K‐glypican), a GPI‐anchored cell surface HSPG, is involved in the regulation of FGF2 action during cortical neurogenesis, and the spatiotemporal expression pattern of glypicans‐4 in the developing cerebral wall significantly overlaps with that of F GF2. Expand
Cell surface glypicans are low-affinity endostatin receptors.
It is shown that glypicans serve as low-affinity receptors for endostatin in these cells, as in endothelial cells, and antisense experiments suggest the critical importance of Glypicans in mediating endostasin activities. Expand
Protracted Withdrawal from Alcohol and Drugs of Abuse Impairs Long-Term Potentiation of Intrinsic Excitability in the Juxtacapsular Bed Nucleus of the Stria Terminalis
A form of long-term potentiation of the intrinsic excitability (LTP-IE) of jcBNST neurons in response to high-frequency stimulation of the stria terminalis is shown. Expand
Synbindin, a Novel Syndecan-2–Binding Protein in Neuronal Dendritic Spines
The results show that synbindin is a physiological syndecan-2 ligand on dendritic spines, and suggest that syndecon-2 induces spine formation by recruiting intracellular vesicles toward postsynaptic sites through the interaction with syn bindin. Expand
The Proteoglycan Lectin Domain Binds Sulfated Cell Surface Glycolipids and Promotes Cell Adhesion*
  • R. Miura, A. Aspberg, +4 authors Yu Yamaguchi
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 16 April 1999
The findings demonstrate that the interaction between the lectin domains of lecticans and sulfated glycolipids comprises a novel cell substrate recognition system, and suggest that lecticans in extracellular matrices serve as substrate for adhesion and migration of cells expressing these glycolIPids in vivo. Expand
Brevican in the developing hippocampal fimbria: Differential expression in myelinating oligodendrocytes and adult astrocytes suggests a dual role for brevican in central nervous system fiber tract
It is demonstrated that the authentic, secreted form of brevican, not the glycosylphosphatidylinositol‐anchored variant, is the predominant species expressed in the developing fimbria, and the results suggest thatbrevican plays a dual role in developing and adult fiber tracts. Expand