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Mechanisms underlying TGF‐β1‐induced expression of VEGF and Flk‐1 in mouse macrophages and their implications for angiogenesis
TLDR
The results from the present study indicate that TGF‐β1 can activate mouse macrophages to express angiogenic mediators such as VEGF, MMP‐9, and Flk‐1.
Transglutaminase 2: a multi-functional protein in multiple subcellular compartments
TLDR
The biological functions and molecular interactions of TG2 will be discussed in the context of the unique environments of the subcellular compartments to which TG2 localizes, which are important determinants to switch on or off various TG2 biochemical activities.
Hydrogen Peroxide Activates p70S6k Signaling Pathway*
TLDR
The results suggest that ROS act as a messenger in growth factor-induced p70S6k signaling pathway and down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70s6kby ROS.
Nitric oxide prevents 6‐hydroxydopamine‐induced apoptosis in PC12 cells through cGMP‐dependent PI3 kinase/Akt activation
TLDR
The data suggest that the NO/cGMP pathway suppresses 6‐OHDA‐induced PC12 cell apoptosis by suppressing the mitochon‐drial apoptosis signal via PKG/PI3K/Akt‐dependent Bad phosphorylation, and cGMP is a key mediator in NO‐mediated anti‐apoptosis.
Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kappaB activation.
TLDR
Results suggest that the C. pruinosa methanol extract suppresses inflammation through suppression of NF-kappaB-dependent inflammatory gene expression, suggesting that this extract may be beneficial for treatment of endotoxin shock or sepsis.
DNA looping-mediated repression by histone-like protein H-NS: specific requirement of Esigma70 as a cofactor for looping.
TLDR
It is postulated that H-NS bound at -118 laterally extends by the cooperative recruitment of H- NS molecules to the promoter-downstream sequence joined by wrapping of theDNA around Esigma70 .
beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation.
TLDR
The results suggest that beta-carotene possesses anti-inflammatory activity by functioning as a potential inhibitor for redox-based NF-kappaB activation, probably due to its antioxidant activity.
Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation.
TLDR
Astaxanthin, probably due to its antioxidant activity, inhibits the production of inflammatory mediators by blocking NF-kappaB activation and as a consequent suppression of IKK activity and I(kappa)B-alpha degradation.
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