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Initial sequencing and analysis of the human genome.
The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence. Expand
Rates of nucleotide substitution vary greatly among plant mitochondrial, chloroplast, and nuclear DNAs.
The rate of cpDNA evolution appears to have slowed in some dicot lineages following the monocot/dicot split, and the slowdown is more conspicuous at nonsynonymous sites than at synonymous sites. Expand
Widespread Paleopolyploidy in Model Plant Species Inferred from Age Distributions of Duplicate Genes
The unusual age profile of tandem gene duplications in Arabidopsis indicates that other scenarios, such as variation in the rate at which duplicated genes are deleted, must also be considered. Expand
A recent polyploidy superimposed on older large-scale duplications in the Arabidopsis genome.
It is concluded that the Arabidopsis lineage underwent at least two distinct episodes of duplication, one of which was a polyploidy that occurred much more recently than estimated previously and probably during the early emergence of the crucifer family. Expand
Functional Divergence of Duplicated Genes Formed by Polyploidy during Arabidopsis Evolution
Functional diversification of the surviving duplicated genes is a major feature of the long-term evolution of polyploidy, and the rate of protein sequence evolution has been significantly asymmetric in >20% of duplicate pairs. Expand
Molecular evidence for an ancient duplication of the entire yeast genome
A model is proposed in which this species is a degenerate tetraploid resulting from a whole-genome duplication that occurred after the divergence of Saccharomyces from Kluyveromyces, and protein pairs derived from this duplication event make up 13% of all yeast proteins. Expand
SMURF: Genomic mapping of fungal secondary metabolite clusters.
Comparison with genetically characterized clusters from six fungal species showed that SMURF accurately recovered all clusters and detected additional potential clusters and the striking biosynthetic capacity and variability of the fungal SM pathways and the correlation between unicellularity and the absence of SMs. Expand
The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species.
The Yeast Gene Order Browser was developed to facilitate visual comparisons and computational analysis of synteny relationships in yeasts and reconciled different laboratories' lists of paralogous Saccharomyces cerevisiae gene pairs formed by genome duplication. Expand
Function and evolution of a minimal plastid genome from a nonphotosynthetic parasitic plant.
Complete nucleotide sequencing shows that the plastid genome of Epifagus virginiana, a nonphotosynthetic parasitic flowering plant, lacks all genes for photosynthesis and chlororespiration found inExpand
Date of the monocot-dicot divergence estimated from chloroplast DNA sequence data.
The results imply that the angiosperm lineage emerged in Jurassic-Triassic time, which considerably predates its appearance in the fossil record (approximately 120 Myr ago), which can be taken as an upper bound for the age of angiosperms. Expand