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BTB Domain-containing Speckle-type POZ Protein (SPOP) Serves as an Adaptor of Daxx for Ubiquitination by Cul3-based Ubiquitin Ligase*
TLDR
It is shown that SPOP serves as an adaptor of Daxx for the ubiquitination by Cul3-based ubiquitin ligase and subsequent degradation by the proteasome, and SPOP/Cul3-ubiquit in ligase plays an essential role in the control of Dxx level and, thus, in the regulation of DAXx-mediated cellular processes, including transcriptional regulation and apoptosis. Expand
Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.
TLDR
The role of DBC1 sumoylation in the promotion of p53-mediated apoptosis in response to genotoxic stress is established. Expand
ISG15 modification of filamin B negatively regulates the type I interferon‐induced JNK signalling pathway
TLDR
It is shown that type I IFNs induce the conjugation of filamin B by interferon‐stimulated gene 15 (ISG15) and ISGylation acts as a negative feedback regulatory gate for the desensitization of type IIFN‐induced JNK signalling. Expand
Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15.
  • Y. Jeon, M. Jo, +7 authors C. Chung
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2 July 2012
TLDR
It is shown that ISGylation played an essential role in the downregulation of ΔNp63α, and this findings establish ISG15 as a tumor suppressor via its conjugation to ΔN p63α and provide a molecular rationale for therapeutic use of doxorubicin against ΔNP63α-mediated cancers. Expand
USP47 and C Terminus of Hsp70-Interacting Protein (CHIP) Antagonistically Regulate Katanin-p60-Mediated Axonal Growth
TLDR
It is shown that USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate the stability of katanin-p60 and thereby axonal growth. Expand
Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme
TLDR
These findings indicate that CHIP and USP2 show antagonistic functions in the control of AIF-mediated cell death, and implicate the role of the enzymes as a switch for cells to live or die under stresses that cause tAIF release. Expand
c-Cbl regulates αPix-mediated cell migration and invasion.
TLDR
Results indicate that c-Cbl negatively regulates αPix-mediated cell migration and invasion and the lack of c- Cbl in the C6 and A172 glioma cells is responsible for their malignant behavior. Expand
Chemosensitivity is controlled by p 63 modification with ubiquitin-like protein ISG 15
Identification of the cellular mechanisms that mediate cancer cell chemosensitivity is important for developing new cancer treatment strategies. Several chemotherapeutic drugs increase levels of theExpand