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Sensitization of cells and retroviruses to human serum by (αl-3) galactosyltransferase
It is demonstrated that anti-Gal(αl–3)Gal antibodies in human serum inactivate retroviruses produced from animal cells and renders the cells and the retrovirus they produce sensitive to human serum. Expand
Cloning and sequence analysis of 14 DRB alleles of the bovine major histocompatibility complex by using the polymerase chain reaction.
- S. Sigurdardóttir, C. Borsch, K. Gustafsson, L. Andersson
- Biology, Medicine
- Animal genetics
- 24 April 2009
The significantly higher frequency of replacement substitutions compared with the frequency of silent substitutions provides strong evidence that there is selection for genetic diversity in the bovine DRB3 first domain exon and a comparison of the DRB polymorphism in man and cattle reveals a striking similarity. Expand
Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation
- A. Capsomidis, Gabriel Benthall, +9 authors John Anderson
- Chemistry, Medicine
- Molecular therapy : the journal of the American…
- 8 December 2017
It is shown that γδT cells of both Vδ1 and V δ2 subsets could be expanded and transduced to sufficient numbers for clinical studies and show promise for evaluation in clinical studies of solid tumors. Expand
HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complement-mediated inactivation.
Investigation of whether ABO sugars are incorporated into the envelope of HIV-1 virions found that HIV vectors derived from cells expressing ABO antigens displayed sensitivity to fresh human serum analogous to ABO incompatibility, and ABO histo-blood group sugars were detected on the viral envelope protein. Expand
Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins
The subunits of immunoglobulins, class I antigens and class II antigen are related evolutionarily, and the complete amino acid sequence is predicted. Expand
Human γδ T Cells: A Lymphoid Lineage Cell Capable of Professional Phagocytosis1
The findings of distinct myeloid characteristics in γδ T cells strongly support the suggestion that γ Δ T cells are evolutionarily ancient lymphocytes and have implications for the understanding of their role in transitional immunity and the control of infectious diseases and cancer. Expand
Expression of ABO or related antigenic carbohydrates on viral envelopes leads to neutralization in the presence of serum containing specific natural antibodies and complement.
Such viral glycosylation may partly explain why the ABO antigens and other similar intraspecies as well as interspecies polymorphic carbohydrates have evolved and been maintained over long evolutionary periods. Expand
Gene duplications and sequence polymorphism of bovine class II DQB genes
Bovine DQB genes were found to be highly polymorphic as ten DQB1 alleles and four DQB2 alleles were identified and the frequency of silent substitutions between DQB alleles was markedly lower in cattle than in humans, in agreement with a previous comparison of human and bovine DRB alleles. Expand
Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related mammalian species.
- K. Gustafsson, S. Germana, F. Hirsch, K. Pratt, C. Leguern, D. Sachs
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 December 1990
Examination of cDNA clones corresponding to DRB genes from two major histocompatibility complex homozygous strains revealed a homology in hypervariable residues between the human DRB1-1401 allele and the mouse E beta s allele as well as a cow DRB allele, suggesting the existence of selective mechanisms that have resulted in similar hypervariable regions in certain alleles even in these widely disparate species. Expand
Human γδ T Lymphocytes Are Licensed for Professional Antigen Presentation by Interaction with Opsonized Target Cells
- Nourrédine Himoudi, D. Morgenstern, +6 authors John Anderson
- Biology, Medicine
- The Journal of Immunology
- 15 February 2012
It is proposed that licensing by Ab is a mechanism whereby the adaptive properties of γδ T cells are induced by their innate functions in a spatially and temporally controlled manner. Expand