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In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity.
TLDR
It is demonstrated that the P-4503A inhibitor TAO can be used to effectively modulate CPA metabolism and pharmacokinetics in vivo in a manner that decreases the formation of toxic metabolites that do not contribute to antitumor activity. Expand
Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma
TLDR
Results suggest that concurrent ligation of CB1 and CB2 with either R(+)-MA or Win55 induces apoptosis via a sequence of events in MCL cells: accumulation of ceramide, phosphorylation of p38, depolarization of the mitochondrial membrane, and caspase activation. Expand
Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism
TLDR
It is suggested that R-MA induces cell death in MCL via CB1-mediated up-regulation of the de novo ceramide synthesis pathway and this is the first study were the cytotoxic effect of a cannabinoid is enhanced by modulation of ceramide metabolism. Expand
Expression of cannabinoid receptors type 1 and type 2 in non‐Hodgkin lymphoma: Growth inhibition by receptor activation
TLDR
The results suggest that therapies using cannabinoid receptor ligands will have efficiency in reducing tumor burden in malignant lymphoma overexpressing CB1 and CB2. Expand
Biochemical pharmacology of the atypical neuroleptic remoxipride
Abstract In vitro receptor ligand binding studies in the rat showed that remoxipride displaced different radioligands at the dopamine D2, but not the D1 receptor. Remoxipride did not blockExpand
Biochemical pharmacology of the atypical neuroleptic remoxipride
TLDR
Findings suggest that remoxipride acts at both the central D2 and sigma receptors and that its affinity for the D2 receptor is relatively low in vitro and in vivo. Expand
Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
TLDR
The data suggest that cannabinoid receptors may be considered as potential therapeutic targets in MCL, and treatment with cannabinoid receptor ligands caused a decrease in viability of MCL cells, while control cells lacking CB1 were not affected. Expand
Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.
TLDR
Specific roles for P450 2B and 3A enzymes in catalysing these pathways of IF metabolism in vivo are demonstrated, and the potential for modulation of IF's alternative metabolic pathways in a therapeutically useful manner is demonstrated. Expand
Remoxipride shows low propensity to block functional striatal dopamine D2 receptors in vitro.
TLDR
The results demonstrate that remoxipride is significantly weaker in blocking functional striatal dopamine D2 receptors than either of the reference compounds studied and three of the four metabolites. Expand
Biochemical pharmacology of the atypical neuroleptic remoxipride
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