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Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals.
TLDR
It is reported that serotonin deficiency results in a reduction of mammary PTHrP expression during lactation, which is rescued by restoring 5-HT synthesis, which connects 5- HT synthesis to the induction of bone-regulating factors in the normal mammary gland and in breast cancer cells. Expand
Prolactin actions.
TLDR
In this review, several advances in knowledge ofPRL actions are highlighted and special emphasis is paid to areas of progress with consequences for understanding of human PRL actions. Expand
D2 dopamine receptor activation of potassium channels in identified rat lactotrophs: whole-cell and single-channel recording
TLDR
It is established that in primary rat lactotrophs, DA acts at D2 receptors to activate the opening of single K+ channels, which results in an increase in K+ conductance and associated membrane hyperpolarization, which is the first characterization of single DA-activated K- channels in an endocrine cell. Expand
Identification of G protein-coupled, inward rectifier potassium channel gene products from the rat anterior pituitary gland.
TLDR
GIRK1 and GIRK4 are excellent candidate subunits for the D(2)-activated, G protein-gated channel in pituitary lactotropes, where they play a critical role in excitation-secretion coupling. Expand
Stimulation of prolactin release by dopamine withdrawal: role of calcium influx.
TLDR
It is demonstrated that a period of increased Ca(2+)-spiking activity follows recovery from the DA-induced hyperpolarization, and that influx of extracellular Ca2+ through verapamil-sensitive channels is a critical step in inducing PRL release after DA withdrawal. Expand
Serotonin transport and metabolism in the mammary gland modulates secretory activation and involution.
TLDR
Medications that perturb serotonin balance dysregulate lactation, and the effects are consistent with those predicted by the physiological effects of intramammary 5-HT bioactivity, may need additional support to achieve their breastfeeding goals. Expand
Influences of luteinizing hormone releasing hormone, hypophysectomy and orchidectomy on the differentiation of luteinizing hormone and follicle-stimulating hormone cells and in an ectopic pituitary
TLDR
The resemblance of the development of gonadotrophs in the in situ pituitary with that in ectopic pituitaries in hosts treated with LHRH suggests that L HRH may be a major determinant of normal gonadOTroph differentiation. Expand
Dopamine withdrawal elicits prolonged calcium rise to support prolactin rebound release.
TLDR
The data demonstrate that the rebound secretion of PRL is dependent upon enhanced influx of extracellular Ca2+ after cells recover from DA-induced hyperpolarization and support the hypothesis that a population of inactivated Ca 2+ channels has been recruited in response to application and withdrawal of DA. Expand
Enhanced Responsiveness to Selective Serotonin Reuptake Inhibitors during Lactation
TLDR
Findings demonstrate changes in both central and peripheral 5-HT systems associated with lactation, independent of pregnancy and demonstrate a significant interaction of lactation and responsiveness to SSRI treatment, which has important implications in the treatment of PPD. Expand
Stimulation of prolactin release by dopamine withdrawal: role of membrane hyperpolarization.
TLDR
Novel results demonstrate that hyperpolarization of the lactotrope membrane by DA is critical for the development of PRL rebound after DA withdrawal, and hypothesize the mechanism involves the removal of inactivation from a population of Ca2+ channels, leading to enhancedCa2+ influx and PRL release upon recovery of the resting membrane potential after DA removal. Expand
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