• Publications
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Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages
The capacity of MNV-1 to replicate in a STAT-1-regulated fashion and the unexpected tropism of a norovirus for cells of the hematopoietic lineage provide important insights into Norovirus biology. Expand
Taxonomy of the caliciviruses.
The International Committee on Taxonomy of Viruses (ICTV) has recently approved several proposals submitted by the present Caliciviridae Study Group. These proposals include the division of theExpand
Proposal for a unified norovirus nomenclature and genotyping
It is demonstrated that the pairwise distance cutoff method can no longer be used and a phylogenetic approach to classify noroviruses is outlined and a dual nomenclature using both ORF1 and VP1 sequences is proposed, as recombination is common and recognizing recombinant viruses may be relevant. Expand
Evolutionary Dynamics of GII.4 Noroviruses over a 34-Year Period
Analysis of archival G II.4 norovirus strains suggests that this genotype has been circulating for more than three decades and provides new ancestral strain sequences for the analysis of GII.4 evolution. Expand
Processing Map and Essential Cleavage Sites of the Nonstructural Polyprotein Encoded by ORF1 of the Feline Calicivirus Genome
Three new cleavage sites recognized by the virus proteinase in the N-terminal part of the open reading frame 1 (ORF1) polyprotein are mapped to complete the processing map and indicate that these cleavages are essential in a productive virus infection. Expand
Mapping of the Feline Calicivirus Proteinase Responsible for Autocatalytic Processing of the Nonstructural Polyprotein and Identification of a Stable Proteinase-Polymerase Precursor Protein
  • Svetlana A. Sosnovtseva, Stanislav V. Sosnovtsev, K. Green
  • Medicine, Biology
  • Journal of Virology
  • 1 August 1999
Immunoprecipitation of radiolabeled proteins from FCV-infected feline kidney cells with serum raised against the FCV ORF1 C-terminal region showed that this “3CD-like” proteinase-polymerase precursor protein is apparently stable and accumulates in cells during infection. Expand
In Vitro Proteolytic Processing of the MD145 Norovirus ORF1 Nonstructural Polyprotein Yields Stable Precursors and Products Similar to Those Detected in Calicivirus-Infected Cells
A model for proteolytic processing in the noroviruses is established that is consistent with nonstructural precursors and products identified in studies of caliciviruses that replicate in cell culture systems. Expand
Norovirus gastroenteritis in immunocompromised patients.
  • K. Bok, K. Green
  • Medicine
  • The New England journal of medicine
  • 28 November 2012
Genetic features and emerging treatments of norovirus, the most common cause of gastroenteritis in U.S. adults seeking emergency department care, are discussed. Expand
Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line.
expression of replicon RNA was significantly reduced in the presence of interferon (IFN)-alpha in a dose-dependent manner in the NV replicon-bearing cells, suggesting a role for innate immunity in the control of human norovirus replication. Expand
Diarrheal disease during Operation Desert Shield.
Gastroenteritis caused by enterotoxigenic E. coli and shigella resistant to a number of drugs was a major problem that frequently interfered with the duties of U.S. troops during Operation Desert Shield. Expand