• Publications
  • Influence
Proc of SPIE
  • 3,403
  • 296
Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis
To provide a stable environmental barrier, the epidermis requires an integrated network of cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the body's mostExpand
  • 303
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Desmosomal Dysfunction due to Mutations in Desmoplakin Causes Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is characterized by progressive degeneration of the right ventricular myocardium, ventricular arrhythmias, fibrous-fattyExpand
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  • PDF
Plakins: a family of versatile cytolinker proteins.
By connecting cytoskeletal elements to each other and to junctional complexes, the plakin family of cytolinkers plays a crucial role in orchestrating cellular development and maintaining tissueExpand
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Working out the strength and flexibility of desmosomes
Desmosomes have long been regarded as essential 'spot welds' that externally glue together cells within a tissue, and internally anchor the cytoskeletal network of intermediate filaments.Expand
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p120 catenin associates with kinesin and facilitates the transport of cadherin–catenin complexes to intercellular junctions
p120 catenin (p120) is a component of adherens junctions and has been implicated in regulating cadherin-based cell adhesion as well as the activity of Rho small GTPases, but its exact roles inExpand
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Desmosomes: new perspectives on a classic.
  • K. Green, C. Simpson
  • Biology, Medicine
  • The Journal of investigative dermatology
  • 1 November 2007
Desmosomes are highly specialized anchoring junctions that link intermediate filaments to sites of intercellular adhesion, thus facilitating the formation of a supracellular scaffolding thatExpand
  • 355
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Protein Binding and Functional Characterization of Plakophilin 2
Plakophilins are a subfamily of p120-related arm-repeat proteins that can be found in both desmosomes and the nucleus. Among the three known plakophilin members, plakophilin 1 has been linked to aExpand
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Defining desmosomal plakophilin-3 interactions
Plakophilin 3 (PKP3) is a recently described armadillo protein of the desmosomal plaque, which is synthesized in simple and stratified epithelia. We investigated the localization pattern ofExpand
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Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Desmosomes are intercellular junctions in which cadherin cell adhesion molecules are linked to the intermediate filament (IF) system. Desmoplakin is a member of the plakin family of IF-bindingExpand
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