Share This Author
Studies on T lymphocyte activation II. The target cells for concanavalin A‐induced growth factors
Growth factors contained in Con A‐CM maintain exponential growth in T cell blasts derived from mitogen stimulation of spleen cells with Con A, phytohemagglutinin, lentil lectin and pokeweed mitogen (PWM), as well as from mixed lymphocyte reactions to H‐2 D or I‐E and I‐C‐encoded determinants and from non‐H‐2 Mls locus‐controlled reactions.
The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits the activation of antigen-specific T-cells in mice.
Long term growth in vitro of human T cell blasts with maintenance of specificity and function.
Human T lymphoblasts obtained via antigenic stimulation and gradient centrifugation purification can be maintained as perpetual dividing cells in vitro , retaining specificity and function. By…
Studies on T lymphocyte activation I. Requirements for the mitogen‐dependent production of T cell growth factors
- J. Andersson, K. Grönvik, E. Larsson, A. Coutinho
- Biology, MedicineEuropean journal of immunology
- 1 August 1979
Conditioned media obtained from concanavalin A‐stimulated spleen cell cultures maintain mitogen‐derived T cell blasts in exponential growth for indefinite periods of time, but the appearance of activity in CM is Con A dose‐dependent.
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treatment in vivo on thymocyte functions in mice after activation in vitro.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induced suppression of the local immune response.
IgE-Mediated Enhancement of CD4+ T Cell Responses in Mice Requires Antigen Presentation by CD11c+ Cells and Not by B Cells
The findings argue against the idea that IgE-mediated enhancement of specific CD4+ T cell responses in vivo is caused by increased antigen presentation by B cells, and propose a model where CD23+ B cells act as antigen transporting cells, delivering antigen to CD11c+ cells for presentation to T cells.
Influenza Infection in Mice Induces Accumulation of Lung Mast Cells through the Recruitment and Maturation of Mast Cell Progenitors
It is speculated that temporary augmented numbers of lung MCs are a cause behind virus-induced exacerbations of MC-related lung diseases such as asthma.
Preparation and characterization of specific monoclonal antibodies for the detection of adult worm infections in onchocerciasis.
Three monoclonal antibodies were prepared and evaluated in a sandwich enzyme-linked immunosorbent assay (ELISA) for their abilities to detect circulating adult worm antigens in onchocercal bovine and human sera and concluded that the MAbs could be field tested and used in responder populations or employed as components of more sensitive assays for the evaluation of novel OnChocerca macrofilaricides.