K. Gillis

Publications79
h-index33
Citations3,370
Highly Influential Citations180
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Protein Kinase C Enhances Exocytosis from Chromaffin Cells by Increasing the Size of the Readily Releasable Pool of Secretory Granules
Techniques for Membrane Capacitance Measurements
TLDR
Capacitance-recording techniques can almost achieve the resolution of synaptic preparations, where the electrical response of a postsynaptic cell serves as a reporter of secretion.
A metabolite-regulated potassium channel in rat pancreatic B cells.
TLDR
In B cells from dispersed rat islet of Langerhans, the presence of a metabolically regulated K+ channel gated by intracellular concentrations of ATP or the ratio of ATP/ADP concentrations is suggested.
Admittance-based measurement of membrane capacitance using the EPC-9 patch-clamp amplifier
  • K. Gillis
  • Computer Science
    Pflügers Archiv
  • 18 February 2000
TLDR
A software lock-in amplifier developed to allow high-time-resolution measurement of membrane capacitance as a single-cell assay of exocytosis is thoroughly integrated with a computer-controlled patch-clamp amplifier to allow estimation of equivalent circuit parameters based upon calibrated admittance measurements.
Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels by Adenosine Triphosphate Hydrolysis
TLDR
Kinetic analysis of K1250A-CFTR, a mutant that abolishes ATP hydrolysis at NBD2, reveals the presence of two open states and suggests that the channel can close without nucleotide interaction with N BD2.
A Highly Ca2+-sensitive Pool of Granules Is Regulated by Glucose and Protein Kinases in Insulin-secreting INS-1 Cells
TLDR
It is concluded that glucose and second messengers can modulate insulin release triggered by a high-affinity Ca2+ sensor that is poised to respond to modest, global elevations of [Ca2+]i.
Design of a CMOS Potentiostat Circuit for Electrochemical Detector Arrays
TLDR
Design criteria for a potentiostat circuit that is capable of measuring transient amperometric oxidation currents at the surface of an electrode with submillisecond time resolution and picoampere current resolution are presented.
Electrophysiology of stimulus-secretion coupling in human beta-cells.
TLDR
It is suggested that combinations of Cm measurements and electrical activity/membrane current measurements may help define the roles of diverse electrical activity patterns, displayed by human beta-cells, in stimulus-induced insulin secretion.
Electrophysiology of Stimulus-Secretion Coupling in Human β-Cells
TLDR
It is suggested that combinations of Cm measurements and electrical activity/membrane current measurements may help define the roles of diverse electrical activity patterns, displayed by human β-cells, in stimulus-induced insulin secretion.
A highly Ca2+-sensitive pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells
TLDR
In chromaffin cells, PKC enhances exocytosis both by increasing the number of readily releasable vesicles and by shifting vesicle to a highly Ca2+-sensitive state, enabling exocyTosis at sites relatively distant from Ca2+, using flash photolysis and membrane capacitance measurements.
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