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Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics
The complete 1,751,377-bp sequence of the genome of the thermophilic archaeon Methanobacterium thermoautotrophicum deltaH has been determined by a whole-genome shotgun sequencing approach. A total of
The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors
TLDR
Findings indicating that GMX1778 is a potent and specific inhibitor of the NAD+ biosynthesis enzyme nicotinamide phosphoribosyltransferase (NAMPT) indicate that cancer cells have a very high rate of NAD+ turnover, which makes NAD+ modulation an attractive target for anticancer therapy.
Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777
TLDR
Results indicate that nicotinic acid is a potent antidote to treat GMX1777 overdose and support the design of an open-label, dose-escalation trial, in which patients with refractory solid tumors and lymphomas receive 24 h infusions of GMX 1777 as a single agent in 3-week cycles.
Mutational analysis of the mouse mitochondrial cytochrome b gene.
Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary tumors and DNA adducts by dietary selenite.
TLDR
It is demonstrated that selenite can inhibit the initiation stage of mammary carcinogenesis and reduce the tumor incidence, likely due to a reduction in carcinogen metabolism and ultimately adduct formation.
Modulation of bacteriolysis by cooperative effects of penicillin-binding proteins 1a and 3 in Escherichia coli
TLDR
It is concluded that cooperative effects between PBPs in E. coli can lead to a dissociation of bacterial killing and lysis, which is highly bactericidal without causing cell wall degradation or lysis.
Sequence Analysis of Mammalian Cytochrome b Mutants
TLDR
Biochemical and somatic cell genetic analyses indicated that resistance phenotypes to inhibitors of electron transport through the protonmotive cytochrome h of Complex III were determined by mutations within the mitochondrial gene encoding the apocytochrome b.