• Publications
  • Influence
Tissue engineering for cutaneous wounds.
Skin, the largest organ in the body, protects against toxins and microorganisms in the environment and serves to prevent dehydration of all non-aquatic animals. Immune surveillance, sensoryExpand
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Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties.
To successfully induce tissue repair or regeneration in vivo, bioengineered constructs must possess both optimal bioactivity and mechanical strength. This is because cell interaction with theExpand
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TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling
Cyclic mechanical strain produced by pulsatile blood flow regulates the orientation of endothelial cells lining blood vessels and influences critical processes such as angiogenesis. MechanicalExpand
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Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels
Bio-Inspired Drug Delivery Noting that platelets naturally migrate to narrowed blood vessels characterized by high fluid shear stress, Korin et al. (p. 738, published online 5 July; see theExpand
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Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro
Tumor blood vessels exhibit abnormal structure and function that cause disturbed blood flow and high interstitial pressure, which impair delivery of anti-cancer agents. Past efforts to normalize theExpand
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Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing.
Fibronectin (FN) facilitates dermal fibroblast migration during normal wound healing. Proteolytic degradation of FN in chronic wounds hampers healing. Previously, three FN functional domains (FNfd)Expand
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Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy
Tumor vessels are characterized by abnormal morphology and hyperpermeability that together cause inefficient delivery of chemotherapeutic agents. Although vascular endothelial growth factor has beenExpand
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Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix.
A cancer nanotherapeutic has been developed that targets the extracellular matrix (ECM)-modifying enzyme lysyl oxidase (LOX) and alters the ECM structure. Poly(d,l-lactide-co-glycolide) nanoparticlesExpand
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Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment.
Studies have established that pigmentation can provide strong, protective effects against certain human diseases. For example, angiogenesis-dependent diseases such as wet age-related macularExpand
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Attachment and spreading of fibroblasts on an RGD peptide-modified injectable hyaluronan hydrogel.
  • X. Shu, K. Ghosh, +4 authors G. Prestwich
  • Materials Science, Medicine
  • Journal of biomedical materials research. Part A
  • 1 February 2004
Hyaluronan (HA) hydrogels resist attachment and spreading of fibroblasts and most other mammalian cell types. A thiol-modified HA (3,3'-dithiobis(propanoic dihydrazide) [HA-DTPH]) was modified withExpand
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