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Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
BACKGROUND The Rho GTPases Rho, Rac, and Cdc42 regulate the organization of the actin cytoskeleton by interacting with multiple, distinct downstream effector proteins. Cdc42 controls the formation ofExpand
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Improved visualization of protein consensus sequences by iceLogo
To the Editor: Large sequence-based datasets are often scanned for conserved sequence patterns to extract useful biological information1. Sequence logos2 have been developed to visualize conservedExpand
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Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability
Many mitochondrial proteins are synthesized with N-terminal presequences that are removed by specific peptidases. The N-termini of the mature proteins and thus peptidase cleavage sites have only beenExpand
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Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans
Nα-terminal acetylation is one of the most common protein modifications in eukaryotes. The COmbined FRActional DIagonal Chromatography (COFRADIC) proteomics technology that can be specifically usedExpand
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LNCipedia: a database for annotated human lncRNA transcript sequences and structures
We present LNCipedia, a novel database for human long non-coding RNA (lncRNA) transcripts and genes. Expand
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T‐cell receptor‐induced JNK activation requires proteolytic inactivation of CYLD by MALT1
The paracaspase mucosa‐associated lymphoid tissue 1 (MALT1) is central to lymphocyte activation and lymphomagenesis. MALT1 mediates antigen receptor signalling to NF‐κB by acting as a scaffoldExpand
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Protein N-terminal acetyltransferases: when the start matters.
The majority of eukaryotic proteins are subjected to N-terminal acetylation (Nt-acetylation), catalysed by N-terminal acetyltransferases (NATs). Recently, the structure of an NAT-peptide complex wasExpand
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Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides
Current non-gel techniques for analyzing proteomes rely heavily on mass spectrometric analysis of enzymatically digested protein mixtures. Prior to analysis, a highly complex peptide mixture isExpand
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LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis
LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using genetic andExpand
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ANGUSTIFOLIA3 Binds to SWI/SNF Chromatin Remodeling Complexes to Regulate Transcription during Arabidopsis Leaf Development[W]
The transcriptional coactivator ANGUSTIFOLIA3 (AN3) stimulates cell division during Arabidopsis leaf development. It is shown that AN3 associates with SWI/SNF chromatin remodeling complexes toExpand
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