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Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats.
- M. King, I. Badea, Jason Solomon, Praveen Kumar, K. Gaspar, M. Foldvari
- Biology, MedicineDiabetes technology & therapeutics
The Biphasix system successfully delivered insulin transdermally, as evidenced by a significant sustained decrease in blood glucose in diabetic rats, with a corresponding increase in serum insulin, which supports the feasibility of developing a transdermal insulin patch for human applications.
Cloning a chloride conductance mediator from the apical membrane of porcine ileal enterocytes.
Attempts to attribute ileal brush-border chloride conductance to specific proteins were pursued by screening a porcine intestinal cDNA library, leading to the isolation of a 3.1-kb full-length sequence called pCLCA1, consistent with the identification of a 2.9-kb transcript through Northern analysis.
Production and characterization of a camelid single domain antibody-urease enzyme conjugate for the treatment of cancer.
- B. Tian, W. Wong, E. Hegmann, K. Gaspar, Praveen Kumar, H. Chao
- Biology, ChemistryBioconjugate chemistry
- 14 May 2015
A novel immunoconjugate (L-DOS47) was developed and characterized as a therapeutic agent for tumors expressing CEACAM6 and is being investigated as a potential therapeutic agent in human phase I clinical studies for nonsmall cell lung cancer.
Monoclonal antibody against conductive chloride transport in pig ileal apical membrane vesicles.
It is reported that anti-chloride conductance monoclonal antibodies did not detect any antigen in Western blots of enterocyte apical membrane protein, and Dot blotting and immunoprecipitation experiments indicated that the antigen recognized by these monoconal antibodies was not the cystic fibrosis transmembrane conductance regulator.
Biphasic vesicles for topical delivery of interferon alpha in human volunteers and treatment of patients with human papillomavirus infections.
Biphasic vesicles delivered clinically significant levels of IFN α across intact human skin and elicited marked therapeutic effect in patients, and was developed as an alternative to injections used to treat human papillomavirus (HPV) infections.
Isoform-specific exon skipping in a variant form of ClC-2.
Inhibition of ileal brush-border chloride conductance by specific antibody
Antibody raised in mice was used in attempting to identify proteins responsible for the conductive chloride transport that can be measured in porcine ileal brush border membrane vesicles, and produced antibody that reacted with at least seven distinct protein bands by Western blot assay and inhibited chloride conductance in brush-border membraneVesicles.
Abstract A74: CAR-T cells harboring camelid single domain antibody as targeting agent to CEACAM6 antigen in pancreatic cancer
The results strongly support that CEACAM6-CAR-T cells can be used as an effective immunotherapy agent against CEACam6-expressing cancers, and that camelid single domain antibodies can be easily adopted for CAR-T type therapies.
Abstract A144: Urease-mediated alkalization of tumor microenvironment and its effects on T cell proliferation, cytokine release, and PD-1/PD-L1 interactions
The novel immunoconjugate L-DOS47, which is in Phase I/II testing for non-small cell lung cancer, was used to augment the extracellular pH of acidified culture media that mimics the tumor microenvironment in vitro and its effects on the human T lymphoblastoid cell line Jurkat Clone E6-1 were examined.