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Weight-reducing effects of the plasma protein encoded by the obese gene.
The gene product of the ob locus is important in the regulation of body weight. The ob product was shown to be present as a 16-kilodalton protein in mouse and human plasma but was undetectable in… Expand
Winged helix proteins.
The winged helix proteins constitute a subfamily within the large ensemble of helix-turn-helix proteins. Since the discovery of the winged helix/fork head motif in 1993, a large number of… Expand
Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding
Regulatory factor X (RFX) proteins are transcriptional activators that recognize X-boxes (DNA of the sequence 5′-GTNRCC(0–3N)RGYAAC-3′, where N is any nucleotide, R is a purine and Y is a pyrimidine)… Expand
HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria.
The X-ray crystal structure of the Escherichia coli stress response protein HDEA has been determined at 2.0 A resolution. The single domain alpha-helical protein is found in the periplasmic space,… Expand
Forces contributing to the conformational stability of proteins
- C. Pace, B. Shirley, M. Mcnutt, K. Gajiwala
- Chemistry, Medicine
- FASEB journal : official publication of the…
- 1 January 1996
For 35 years, the prevailing view has been that the hydrophobic effect is the dominant force in protein folding. The importance of hydrogen bonding was always clear, but whether it made a net… Expand
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients
- K. Gajiwala, J. C. Wu, +19 authors G. Demetri
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 3 February 2009
Most gastrointestinal stromal tumors (GISTs) exhibit aberrant activation of the receptor tyrosine kinase (RTK) KIT. The efficacy of the inhibitors imatinib mesylate and sunitinib malate in GIST… Expand
Insights into the aberrant activity of mutant EGFR kinase domain and drug recognition.
The oncogenicity of the L858R mutant form of the epidermal growth factor receptor (EGFR) in non-small-cell lung cancer is thought to be due to the constitutive activation of its kinase domain. The… Expand
Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme
FabH (β‐ketoacyl‐acyl carrier protein synthase III) is unique in that it initiates fatty acid biosynthesis, is inhibited by long‐chain fatty acids providing means for feedback control of the process,… Expand
Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal.
DNA ligase is an enzyme important for DNA repair and replication. Eukaryotic genomes encode ligases requiring ATP as the cofactor; bacterial genomes encode NAD(+)-dependent ligase. This difference in… Expand
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Overexpression of the complex and point mutations in the… Expand