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Endothelial-mural cell signaling in vascular development and angiogenesis.
TLDR
This review summarizes the five currently best understood signaling pathways implicated in mural cell biology and discusses PDGFB/PDGFRbeta- dependent pericyte recruitment, as well as the role of angiopoietins and Tie receptors in vascular maturation. Expand
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2.
TLDR
It is shown that S1PR1, a receptor for the blood-borne bioactive lipid sphingosine-1-phosphate (S1P), is critical for inhibition of angiogenesis and acquisition of vascular stability, and suggested that it acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses. Expand
Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6
TLDR
It is shown that rlt is a rotation-specific allele of the inhibitory Egfr ligand Argos and that modulation of Egfr activity shows defects in ommatidial rotation, and the involvement of the cadherin Flamingo, a PCP gene, downstream of EgFr signaling provides the first link between PCP establishment and the Egfr pathway. Expand
The role of the Drosophila TAK homologue dTAK during development
TLDR
The results suggest that dTAK can act as a JNKKK upstream of JNK in multiple contexts and also other MAPKs in the eye, and that it is not strictly required and thus either redundant or playing only a minor role in the context of embryonic dorsal closure. Expand
Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations.
TLDR
The findings from these fly models provided hypotheses testable in mammalian models, in which these signaling cassettes are largely conserved, and can be used for sensitized screens to identify novel interacting genes as well as for high-throughput screening of therapeutic compounds for NS and PTPN11-related cancers. Expand
Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin–β-catenin
TLDR
The data suggest that Nemo serves as a conserved molecular link between core PCP factors and E-cadherin–β-catenin complexes, promoting cell motility. Expand
Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium
TLDR
The data suggest that Gpr116 modulates endothelial properties, a previously unappreciated function despite the pan-vascular expression of this receptor, and describe a new role in the central nervous system vasculature. Expand
Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain
TLDR
It is shown that integrin αVβ8 activates angiosuppressive TGFβ gradients in the brain, which inhibit endothelial cell sprouting, and suggests that abnormal vascular sprouting and patterning, not BBB dysfunction, underlie developmental cerebral hemorrhage. Expand
Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice
TLDR
Transgenic reporter mice provide an important tool to explore the development of CNS pericytes in health and disease by finding platelet-derived growth factor receptor β gene (Pdgfrb)-driven EGFP reporter expression as a suitable marker for vascular mural cells at the earliest stages of mouse brain vascularization. Expand
Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations
TLDR
It is found that Cdc42 is required for endothelial tip cell selection, directed cell migration and filopodia formation, but dispensable for cell proliferation or apoptosis, and tracking of CDC42-depleted endothelial cells in mosaic retinas suggests that capillary-venous malformations arise as a consequence of defective cell migration. Expand
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