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- Publications
- Influence
Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation.
- M. G. Kellermann, L. M. Sobral, +5 authors R. Coletta
- Biology, Medicine
- Oral oncology
- 1 May 2008
Several lines of evidence demonstrated that the stroma surrounding the tumors plays an important role in the growth and progression of several neoplasms, including oral squamous cell carcinomas… Expand
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas
- F. Seguin, M. A. Carvalho, +6 authors E. Graner
- Biology, Medicine
- British Journal of Cancer
- 14 August 2012
Background:Fatty acid synthase (FASN) is overexpressed and associated with poor prognosis in several human cancers. Here, we investigate the effect of FASN inhibitors on the metastatic spread and… Expand
Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis.
- M. F. de Souza Setubal Destro, Carolina Cavalcanti Bitu, +4 authors R. Coletta
- Biology, Medicine
- International journal of oncology
- 19 November 2009
A growing body of evidence has confirmed the involvement of dysregulated expression of HOX genes in cancer. HOX genes are a family of 39 transcription factors, divided in 4 clusters (HOXA to HOXD),… Expand
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model
- M. Carvalho, K. G. Zecchin, +9 authors E. Graner
- Biology, Medicine
- International journal of cancer
- 1 December 2008
Fatty acid synthase (FASN) is the enzyme responsible for the endogenous synthesis of the saturated fatty acid palmitate. In contrast to most normal cells, malignant cells depend on FASN activity for… Expand
Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells.
- M. Agostini, S. D. Silva, +4 authors E. Graner
- Biology, Medicine
- Oral oncology
- 1 August 2004
Fatty acid synthase (FAS) is the enzyme responsible for the endogenous synthesis of saturated long-chain fatty acids from the precursors acetyl-CoA and malonyl-CoA. A growing body of evidence… Expand
The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas
- M. Agostini, L. Almeida, +10 authors E. Graner
- Biology, Medicine
- Molecular Cancer Therapeutics
- 20 December 2013
Fatty acid synthase (FASN) is the biosynthetic enzyme responsible for the endogenous synthesis of fatty acids. It is downregulated in most normal cells, except in lipogenic tissues such as liver,… Expand
Heterogeneous presence of myofibroblasts in hereditary gingival fibromatosis.
- C. Bitu, L. M. Sobral, +4 authors R. Coletta
- Biology, Medicine
- Journal of clinical periodontology
- 1 June 2006
BACKGROUND/AIM
Hereditary gingival fibromatosis (HGF) fibroblasts are characterized by an increased production of collagen and transforming growth factor-beta1 (TGF-beta1), resulting in a fibrotic… Expand
Serum-starved apoptotic fibroblasts reduce blastocyst production but enable development to term after SCNT in cattle.
- M. Miranda, F. Bressan, +8 authors F. Meirelles
- Biology, Medicine
- Cloning and stem cells
- 21 December 2009
Cell cycle synchronization by serum starvation (SS) induces apoptosis in somatic cells. This side effect of SS is hypothesized to negatively affect the outcome of somatic cell nuclear transfer… Expand
Ovariectomy Reduces the Gelatinolytic Activity and Expression of Matrix Metalloproteinases and Collagen in Rat Molar Extraction Wounds
- K. G. Zecchin, M. C. Pereira, R. Coletta, E. Graner, J. Jorge
- Chemistry, Medicine
- Calcified Tissue International
- 1 February 2005
Osteoporosis is commonly associated with estrogen deficiency. However, the mechanisms by which the lack of this hormone causes bone loss are poorly understood. The bone structure of the oral cavity… Expand
Ovariectomy delays alveolar wound healing after molar extractions in rats.
- M. Pereira, K. G. Zecchin, E. Campagnoli, J. Jorge
- Medicine
- Journal of oral and maxillofacial surgery…
- 1 November 2007
PURPOSE
This study was conducted to investigate the morphological effects of the absence of estrogen on alveolar wound healing of young female rats after tooth extraction.
MATERIALS AND METHODS
A… Expand