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Understanding wiring and volume transmission
The proposal on the existence of two main modes of intercellular communication in the central nervous system (CNS) was introduced in 1986 and called wiring transmission (WT) and volume transmissionExpand
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Adenosine Receptor Heteromers and their Integrative Role in Striatal Function
By analyzing the functional role of adenosine receptor heteromers, we review a series of new concepts that should modify our classical views of neurotransmission in the central nervous system (CNS).Expand
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Endothelin‐1 induced lesions of the frontoparietal cortex of the rat. A possible model of focal cortical ischemia
ENDOTHELIN 1 (ET-1) was unilaterally applied onto the surface of the dorsal frontoparietal cortex of the rat. Cortical blood flow measurements using laser-Doppler flowmetry demonstratedExpand
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Receptor heteromerization in adenosine A2A receptor signaling
Recently evidence has been presented that adenosine A2A and dopamine D2 receptors form functional heteromeric receptor complexes as demonstrated in human neuroblastoma cells and mouse fibroblast Ltk−Expand
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Volume transmission and wiring transmission from cellular to molecular networks: history and perspectives
The present paper deals with a fundamental issue in neuroscience: the inter‐neuronal communication. The paper gives a brief account of our previous and more recent theoretical contributions to theExpand
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Galanin Modulates 5‐Hydroxytryptamine Functions: Focus on Galanin and Galanin Fragment/5‐Hydroxytryptamine1A Receptor Interactions in the Braina
Abstract: The reciprocal interactions between galanin and 5‐HT1A receptors in the rat brain are presented. Galanin and its NH2‐terminal fragments antagonize 5‐HT1A receptor‐mediated transmission atExpand
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Triplet Puzzle: Homologies of Receptor Heteromers
Based on a mathematical approach, we deduce a set of triplet homologies that may be responsible for receptor–receptor interactions. We show how such triplets of amino acid residues and their 'teams'Expand
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Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia
The dopamine (DA) neuron system most relevant for schizophrenia is the meso-limbic-cortical DA system inter alia densely innervating subcortical limbic regions. The field of dopamine D2 receptors andExpand
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Central Glucocorticoid Receptor Immunoreactive Neurons: New Insights into the Endocrine Regulation of the Brain
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