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Trioxacarcins, novel antitumor antibiotics. I. Producing organism, fermentation and biological activities.
A group of antitumor antibiotics with a novel skeleton, trioxacarcins, was discovered in culture broths of actinomycete strain DO-45, which is active against Gram-positive bacteria and experimental murine tumors such as sarcoma 180 and leukemia P388. Expand
Antitumor activity of a novel antitumor antibiotic, quinocarmycin citrate (KW2152).
A novel antitumor antibiotic, 2a,3,4,5,6,6a,7,11b-octahydro-11-methoxy-12-methyl-3,6-imino-1H-2-oxa-11 c- azanaphth(1,2,3-cd)azulene-5-carboxylic acid monocitrate (quinocarmycin citrate; KW2152) wasExpand
Prothracarcin, a novel antitumor antibiotic.
A novel antibiotic, prothracarcin was isolated from the culture broth of Streptomyces umbrosus subsp. raffinophilus DO-62. The antibiotic has the molecular formula of C14H14N2O and belongs to theExpand
In vitro antimicrobial activity of cefpirome, a new cephalosporin with a broad antimicrobial spectrum.
The in vitro activity of cefpirome (HR 810), a new cephalosporin antibiotic having a 2,3-cyclopentenopyridine group in the 3-position side chain, showed a broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria and was as active as cefoperazone, an antipseudomonal agent. Expand
Beta-lactamase stability of cefpirome (HR 810), a new cephalosporin with a broad antimicrobial spectrum
Cefpirome showed strong antimicrobial activity against eight beta-lactamase (cephalosporinase)-producing strains which have become resistant to broad-spectrum cephalosporins; especially against E. coli chi 1037. Expand
In vivo antibacterial activity of cefodizime, a new cephalosporin antibiotic.
The protective effects of cefodizime on experimental infections in mice caused by Staphylococcus aureus Smith, Escherichia coli C-11, Proteus vulgaris GN-76 and Serratia marcescens No. 2 were directly related to its in vitro activity against these strains. Expand
In vitro antibacterial activity and beta-lactamase stability of cefodizime, a new cephalosporin antibiotic.
The in vitro activity and beta-lactamase stability of cefodizime (HR 221), a new cephalosporin, were compared with those of other cephem antibiotics and HR 221 was highly active against Gram-negative bacteria and stable to most drug-inactivating enzyme preparations from various bacterial species. Expand
The acetylation of 6'-amino group of amikacin by a new enzyme prepared from serratia sp.
It was found that 1-N-[(S)-3-Amino-2-hydroxypropionyl]-gentamicin B (HAPA-B, SCH 21420) and gentamicin C2 were hardly inactivated by the enzymes and had effective antimicrobial activities against these strains both in vitro and in vivo. Expand
Antitumor activity of trioxacarcin C.
It inhibited the growth of P388 leukemia cells in vitro and showed significant inhibition on the colony formation of HeLa S3 cells and DNA and RNA synthesis were more strongly inhibited than protein synthesis by trioxacarcin C. Expand
Distribution of cefodizime to exudate in the croton oil-induced rat granuloma pouch and its therapeutic effects on experimental infections in the pouch.
The results suggest that the above pharmacokinetic features of cefodizime compensate for its MICs against organisms displaying lower values for CTX. Expand