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A second generation human haplotype map of over 3.1 million SNPs
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and… Expand
PipMaker--a web server for aligning two genomic DNA sequences.
PipMaker (http://bio.cse.psu.edu) is a World-Wide Web site for comparing two long DNA sequences to identify conserved segments and for producing informative, high-resolution displays of the resulting… Expand
Whole-Genome Patterns of Common DNA Variation in Three Human Populations
Individual differences in DNA sequence are the genetic basis of human variability. We have characterized whole-genome patterns of common human DNA variation by genotyping 1,586,383 single-nucleotide… Expand
VISTA: computational tools for comparative genomics
- K. Frazer, L. Pachter, Alexander Poliakov, E. Rubin, I. Dubchak
- Biology, Computer Science
- Nucleic Acids Res.
- 1 July 2004
Comparison of DNA sequences from different species is a fundamental method for identifying functional elements in genomes. Here, we describe the VISTA family of tools created to assist biologists in… Expand
VISTA : visualizing global DNA sequence alignments of arbitrary length
SUMMARY VISTA is a program for visualizing global DNA sequence alignments of arbitrary length. It has a clean output, allowing for easy identification of similarity, and is easily configurable,… Expand
Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21
Global patterns of human DNA sequence variation (haplotypes) defined by common single nucleotide polymorphisms (SNPs) have important implications for identifying disease associations and human… Expand
Human genetic variation and its contribution to complex traits
The last few years have seen extensive efforts to catalogue human genetic variation and correlate it with phenotypic differences. Most common SNPs have now been assessed in genome-wide studies for… Expand
Common Sequence Polymorphisms Shaping Genetic Diversity in Arabidopsis thaliana
The genomes of individuals from the same species vary in sequence as a result of different evolutionary processes. To examine the patterns of, and the forces shaping, sequence variation in… Expand
A sequence-based variation map of 8.27 million SNPs in inbred mouse strains
A dense map of genetic variation in the laboratory mouse genome will provide insights into the evolutionary history of the species and lead to an improved understanding of the relationship between… Expand
Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.
Long-range regulatory elements are difficult to discover experimentally; however, they tend to be conserved among mammals, suggesting that cross-species sequence comparisons should identify them. To… Expand