• Publications
  • Influence
A second generation human haplotype map of over 3.1 million SNPs
The Phase II HapMap is described, which characterizes over 3.1 million human single nucleotide polymorphisms genotyped in 270 individuals from four geographically diverse populations and includes 25–35% of common SNP variation in the populations surveyed, and increased differentiation at non-synonymous, compared to synonymous, SNPs is demonstrated. Expand
PipMaker--a web server for aligning two genomic DNA sequences.
PipMaker is appropriate for comparing genomic sequences from any two related species, although the types of information that can be inferred depend on the level of conservation and the time and divergence rate since the separation of the species. Expand
Whole-Genome Patterns of Common DNA Variation in Three Human Populations
This work has characterized whole-genome patterns of common human DNA variation by genotyping 1,586,383 single-nucleotide polymorphisms (SNPs) in 71 Americans of European, African, and Asian ancestry and indicates that these SNPs capture most common genetic variation as a result of linkage disequilibrium. Expand
VISTA: computational tools for comparative genomics
The VISTA family of tools created to assist biologists in carrying out comparative analysis of DNA sequences is described and capabilities of the site are illustrated by the analysis of a 180 kb interval on human chromosome 5 that encodes for the kinesin family member 3A (KIF3A) protein. Expand
VISTA : visualizing global DNA sequence alignments of arbitrary length
Vista is a program for visualizing global DNA sequence alignments of arbitrary length that has a clean output, allowing for easy identification of similarity, and is easily configurable, enabling the visualization of alignments at different levels of resolution. Expand
Human genetic variation and its contribution to complex traits
Most common SNPs have now been assessed in genome-wide studies for statistical associations with many complex traits, including many important common diseases, and only a limited amount of the heritable component of any complex trait has been identified. Expand
Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21
High-density oligonucleotide arrays are used in combination with somatic cell genetics to identify a large fraction of all common human chromosome 21 SNPs and to directly observe the haplotype structure defined by these SNPs. Expand
Common Sequence Polymorphisms Shaping Genetic Diversity in Arabidopsis thaliana
To examine the patterns of, and the forces shaping, sequence variation in Arabidopsis thaliana, high-density array resequencing of 20 diverse strains was performed and nonredundant single-nucleotide polymorphisms were identified at moderate false discovery rates. Expand
A sequence-based variation map of 8.27 million SNPs in inbred mouse strains
A dense map of genetic variation in the laboratory mouse genome will provide insights into the evolutionary history of the species and lead to an improved understanding of the relationship betweenExpand
Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.
Characterization of the largest element in yeast artificial chromosome transgenic mice revealed it to be a coordinate regulator of three genes, interleukin-4,interleuk in-13, and interleucin-5, spread over 120 kilobases. Expand