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A critical period for experience-dependent synaptic plasticity in rat barrel cortex
- K. Fox
- BiologyThe Journal of neuroscience : the official…
- 1 May 1992
It is shown that changes in the balance of experience acquired through vibrissae can affect development of connectivity in the barrel cortex and the main locus of plasticity is cortical when deprivations are started at P4 and beyond.
Anatomical pathways and molecular mechanisms for plasticity in the barrel cortex
- K. Fox
- 6 June 2002
Time course of experience-dependent synaptic potentiation and depression in barrel cortex of adolescent rats.
Plasticity could be induced in (S1) barrel cortex of adolescent rats by reducing the complement of vibrissae on one side of the muzzle to a single whisker for a period of 7, 20, or 60 days, and depression of the deprived vibrissa response could not be explained by nonspecific effects.
Spatiotemporal convergence and divergence in the rat S1 “Barrel” cortex
The size and response magnitude of receptive fields were evaluated for cells in the rat cortical barrel‐field by using standard vibrissal deflections of 1.14° and it was found that cells in supragranular layers had small centre‐receptive fields with small excitatory surrounds.
Homeostatic plasticity mechanisms are required for juvenile, but not adult, ocular dominance plasticity
- Adam Ranson, Claire E. J. Cheetham, K. Fox, F. Sengpiel
- BiologyProceedings of the National Academy of Sciences
- 9 January 2012
A transition between homeostatic and long-term potentiation–like plasticity mechanisms with increasing age is revealed, which concludes that increased responsiveness to open-eye stimulation after monocular deprivation during the critical period is aHomeostatic process that depends mechanistically on synaptic scaling during thecritical period, whereas in adult mice it is mediated by a different mechanism that requires αCaMKII autophosphorylation.
Postsynaptic control of plasticity in developing somatosensory cortex
It is reported here that the selective disruption of postsynaptic activation in rat S1 by application of a glutamate receptor antagonist inhibits rearrangements in the somatotopic patterning of thalamocorticalafferents induced by manipulations of the sensory periphery during the critical period.
The role of NMDA receptors in information processing.
In this review, we have concentrated on the parallels between the cellular properties of the NMDA receptor and a variety of functional properties within sensory and motor systems. Of course, the NMDA…
Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity.
Paired activity in layer 2/3 excitatory connections in young adult rat cortex paired activity acts to normalize the strength and quantal parameters of connections, by both pre- and postsynaptic mechanisms.
Critical period for monocular deprivation in the cat visual cortex.
It is concluded that the critical period for monocular deprivation is finally over at approximately 1 yr of age for extragranular layers (layers II, III, V, and VI) in visual cortex of the cat.