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Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders
TLDR
Unravelling the mechanisms that trigger sequelae will improve knowledge of the aetiology of neurodevelopmental psychiatric disorders, enable identification of longitudinal biomarkers of dysfunction and permit predictive screening for novel compounds with potential antipsychotic efficacy. Expand
Animal models of schizophrenia
TLDR
The review highlights the need to develop more comprehensive animal models that more adequately replicate deficits in negative and cognitive symptoms of schizophrenia, and identifies specific rodent behavioural tasks with translational relevance to specific cognitive domains affected in schizophrenia. Expand
5-ht6 receptors.
TLDR
All aspects of the discovery, genetics, distribution, pharmacology and function of the 5-ht(6) receptor, which appears to regulate glutamatergic and cholinergic neuronal activity, warrants the use of the upper case nomenclature. Expand
Long-lasting changes in behavioural and neuroendocrine indices in the rat following neonatal maternal separation: Gender-dependent effects
TLDR
The consistent gender differences confirm and expand existing results showing altered anxiety and stress reactivity in male and female rats. Expand
Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS
TLDR
The overall distribution of 5-HT2C-like immunoreactivity complements previous findings with conventional radioligands and agrees well with reported levels of5- HT2C receptor mRNA. Expand
Negative symptoms of schizophrenia: Clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment
TLDR
An integrative overview of the above issues is included as a platform for this Special Issue of European Neuropsychopharmacology in which five clinical and five preclinical articles treat individual themes in greater detail. Expand
Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies
TLDR
Novel conditional genetic mouse models using the Cre/loxP system to spatially restrict inactivation of Psmc1 (Rpt2/S4) to neurons of either the substantia nigra or forebrain are described, providing the first reproducible genetic platform for identifying new therapeutic targets to slow or prevent neurodegeneration. Expand
Long-term changes in social interaction and reward following repeated MDMA administration to adolescent rats without accompanying serotonergic neurotoxicity
TLDR
MDMA administration to adolescent rats reduced social interaction and enhanced the sub-threshold rewarding effect of cocaine at adulthood, despite an absence of accompanying serotonergic and dopaminergic neurotoxicity. Expand
MDMA: On the translation from rodent to human dosing
TLDR
This paper proposes that using the equation Dhuman1⁄4Danimal Whuman=Wanimal ð Þ (where D is dose in milligram and W is weight in kilogram) allows calculation of equivalent doses in animals and humans and proposes that a similar oral dose is required by human users to achieve a similar effect. Expand
A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze
TLDR
Enhanced retention of spatial learning following both AO and 5-ht6 antagonist administration strongly indicate a role for this receptor in memory processes. Expand
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